T
Takaaki Yasuhara
Researcher at University of Tokyo
Publications - 20
Citations - 916
Takaaki Yasuhara is an academic researcher from University of Tokyo. The author has contributed to research in topics: DNA damage & DNA repair. The author has an hindex of 7, co-authored 16 publications receiving 529 citations. Previous affiliations of Takaaki Yasuhara include Harvard University.
Papers
More filters
Journal ArticleDOI
DNA double-strand break repair pathway regulates PD-L1 expression in cancer cells
Hiro Sato,Atsuko Niimi,Takaaki Yasuhara,Tiara Bunga Mayang Permata,Yoshihiko Hagiwara,Mayu Isono,Endang Nuryadi,Ryota Sekine,Takahiro Oike,Sangeeta Kakoti,Yuya Yoshimoto,Kathryn D. Held,Kathryn D. Held,Yoshiyuki Suzuki,Koji Kono,Kiyoshi Miyagawa,Takashi Nakano,Atsushi Shibata +17 more
TL;DR: The involvement of DSB repair in PD-L1 expression is revealed and mechanistic insight is provided into howPD-L 1 expression is regulated after DSBs, which requires ATM/ATR/Chk1 kinases and IRF1 signalling.
Journal ArticleDOI
Human Rad52 Promotes XPG-Mediated R-loop Processing to Initiate Transcription-Associated Homologous Recombination Repair.
Takaaki Yasuhara,Reona Kato,Yoshihiko Hagiwara,Bunsyo Shiotani,Motohiro Yamauchi,Shinichiro Nakada,Atsushi Shibata,Kiyoshi Miyagawa +7 more
TL;DR: It is suggested that the presence of R-loops around D SBs within transcriptionally active regions promotes accurate repair of DSBs via processing by Rad52 and XPG to protect genomic information in these critical regions from gene alterations.
Journal ArticleDOI
Base excision repair regulates PD-L1 expression in cancer cells.
Tiara Bunga Mayang Permata,Yoshihiko Hagiwara,Hiro Sato,Takaaki Yasuhara,Takahiro Oike,Soehartati Gondhowiardjo,Kathryn D. Held,Kathryn D. Held,Takashi Nakano,Atsushi Shibata +9 more
TL;DR: It is demonstrated that oxidative DNA damage induced by exogenously applied hydrogen peroxide (H2O2) upregulates PD-L1 expression in cancer cells and depletion of the base excision repair (BER) enzyme DNA glycosylase augments PD- L1 upregulation in response to H2O1.
Journal ArticleDOI
3D-structured illumination microscopy reveals clustered DNA double-strand break formation in widespread γH2AX foci after high LET heavy-ion particle radiation
Yoshihiko Hagiwara,Atsuko Niimi,Mayu Isono,Motohiro Yamauchi,Takaaki Yasuhara,Siripan Limsirichaikul,Takahiro Oike,Hiro Sato,Kathryn D. Held,Takashi Nakano,Atsushi Shibata +10 more
TL;DR: This work identified the formation of 3D widespread γH2AX foci after high LET carbon-ion irradiation in G2-phase cells and suggests that high LET heavy-ion particles induce clustered DSB formation on a scale of approximately 1 μm3.
Journal ArticleDOI
CARM1 regulates replication fork speed and stress response by stimulating PARP1.
Marie-Michelle Genois,Jean-Philippe Gagné,Takaaki Yasuhara,Jessica Jackson,Sneha Saxena,Marie-France Langelier,Ivan Ahel,Mark T. Bedford,John M. Pascal,Alessandro Vindigni,Guy G. Poirier,Lee Zou +11 more
TL;DR: In this paper, the authors show that CARM1 associates with replication forks and reduces fork speed independently of its methyltransferase activity, and that the fork speed depends on the level of PARP1 activation.