T
Takahiro K. Fujiwara
Researcher at Kyoto University
Publications - 89
Citations - 9968
Takahiro K. Fujiwara is an academic researcher from Kyoto University. The author has contributed to research in topics: Membrane & Membrane protein. The author has an hindex of 38, co-authored 78 publications receiving 8978 citations. Previous affiliations of Takahiro K. Fujiwara include Nagoya University.
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Journal ArticleDOI
Paradigm Shift of the Plasma Membrane Concept from the Two-Dimensional Continuum Fluid to the Partitioned Fluid: High-Speed Single-Molecule Tracking of Membrane Molecules
Akihiro Kusumi,Chieko Nakada,Ken Ritchie,K. Murase,Kenichi G. N. Suzuki,Hideji Murakoshi,Rinshi S. Kasai,Junko Kondo,Takahiro K. Fujiwara +8 more
TL;DR: The high-speed single-molecule tracking methods are described, and a new model of a partitioned fluid plasma membrane and the involvement of the actin-based membrane-skeleton "fences" and anchored-transmembrane protein "pickets" in the formation of compartment boundaries are critically reviewed.
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Phospholipids undergo hop diffusion in compartmentalized cell membrane
TL;DR: It is proposed that various transmembrane proteins anchored to the actin-based membrane skeleton meshwork act as rows of pickets that temporarily confine phospholipids.
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Ultrafine Membrane Compartments for Molecular Diffusion as Revealed by Single Molecule Techniques
K. Murase,Takahiro K. Fujiwara,Yasuhiro Umemura,Kenichi G. N. Suzuki,Ryota Iino,H. Yamashita,Mihoko Saito,Hideji Murakoshi,Ken Ritchie,Akihiro Kusumi +9 more
TL;DR: The results strongly indicate the necessity for the paradigm shift of the concept on the plasma membrane: from the two-dimensional fluid continuum model to the compartmentalized membrane model in which its constituent molecules undergo hop diffusion over the compartments.
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Relationship of Lipid Rafts to Transient Confinement Zones Detected by Single Particle Tracking
TL;DR: Overall, the data demonstrate that there are raft-related domains present in certain regions of the plasma membrane of C3H cells, which can persist for tens of seconds.
Journal ArticleDOI
Oscillatory control of factors determining multipotency and fate in mouse neural progenitors.
Itaru Imayoshi,Akihiro Isomura,Yukiko Harima,Kyogo Kawaguchi,Hiroshi Kori,Hitoshi Miyachi,Takahiro K. Fujiwara,Fumiyoshi Ishidate,Ryoichiro Kageyama +8 more
TL;DR: Oscillation Stabilizes the Progenitor State Transcription factors regulate fate choice between different neural lineages, but the same transcription factors are also expressed in neural progenitor cells.