T
Takahiro Suzuki
Researcher at Hokkaido University
Publications - 261
Citations - 6822
Takahiro Suzuki is an academic researcher from Hokkaido University. The author has contributed to research in topics: Chemistry & Medicine. The author has an hindex of 33, co-authored 207 publications receiving 5882 citations. Previous affiliations of Takahiro Suzuki include Tokyo University of Marine Science and Technology & Agency for Science, Technology and Research.
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Journal ArticleDOI
An atlas of active enhancers across human cell types and tissues
Robin Andersson,Claudia Gebhard,Irene Miguel-Escalada,Ilka Hoof,Jette Bornholdt,Mette Boyd,Yun Chen,Xiaobei Zhao,Xiaobei Zhao,Christian Schmidl,Takahiro Suzuki,Evgenia Ntini,Erik Arner,Eivind Valen,Eivind Valen,Kang Li,Lucia Schwarzfischer,Dagmar Glatz,Johanna Raithel,Berit Lilje,Nicolas Rapin,Frederik Otzen Bagger,Mette Rose Jørgensen,Peter Refsing Andersen,Nicolas Bertin,Owen J. L. Rackham,A. Maxwell Burroughs,J Kenneth Baillie,Yuri Ishizu,Yuri Shimizu,Erina Furuhata,Shiori Maeda,Yutaka Negishi,Christopher J. Mungall,Terrence F. Meehan,Timo Lassmann,Masayoshi Itoh,Hideya Kawaji,Naoto Kondo,Jun Kawai,Andreas Lennartsson,Carsten O. Daub,Peter Heutink,David A. Hume,Torben Heick Jensen,Harukazu Suzuki,Yoshihide Hayashizaki,Ferenc Müller,Alistair R. R. Forrest,Piero Carninci,Michael Rehli,Albin Sandelin +51 more
TL;DR: It is shown that enhancers share properties with CpG-poor messenger RNA promoters but produce bidirectional, exosome-sensitive, relatively short unspliced RNAs, the generation of which is strongly related to enhancer activity.
Journal ArticleDOI
The transcriptional network that controls growth arrest and differentiation in a human myeloid leukemia cell line
Harukazu Suzuki,Alistair R. R. Forrest,Erik van Nimwegen,Carsten O. Daub,Piotr J. Balwierz,Katharine M. Irvine,Timo Lassmann,Timothy Ravasi,Yuki Hasegawa,Michiel J. L. de Hoon,Shintaro Katayama,Kate Schroder,Piero Carninci,Yasuhiro Tomaru,Mutsumi Kanamori-Katayama,Atsutaka Kubosaki,Altuna Akalin,Yoshinari Ando,Erik Arner,Maki Asada,Hiroshi Asahara,Timothy L. Bailey,Vladimir B. Bajic,Denis C. Bauer,Anthony G Beckhouse,Nicolas Bertin,Johan Björkegren,Frank Brombacher,Erika Bulger,Alistair M. Chalk,Joe Chiba,Nicole Cloonan,Adam Dawe,Josée Dostie,Pär G. Engström,Magbubah Essack,Geoffrey J. Faulkner,J. Lynn Fink,David Fredman,Ko Fujimori,Masaaki Furuno,Takashi Gojobori,Julian Gough,Sean M. Grimmond,Mika Gustafsson,Megumi Hashimoto,Takehiro Hashimoto,Mariko Hatakeyama,Susanne Heinzel,Winston Hide,Winston Hide,Oliver Hofmann,Oliver Hofmann,Michael Hörnquist,Lukasz Huminiecki,Kazuho Ikeo,Naoko Imamoto,Satoshi Inoue,Yusuke Inoue,Ryoko Ishihara,Takao Iwayanagi,Anders Jacobsen,Mandeep Kaur,Hideya Kawaji,Markus C. Kerr,Ryuichiro Kimura,Syuhei Kimura,Yasumasa Kimura,Hiroaki Kitano,Hisashi Koga,Toshio Kojima,Shinji Kondo,Takeshi Konno,Anders Krogh,Adele Kruger,Ajit Kumar,Boris Lenhard,Andreas Lennartsson,Morten Lindow,Marina Lizio,Cameron Ross MacPherson,Norihiro Maeda,Christopher G. Maher,Monique Maqungo,Jessica C. Mar,Nicholas Matigian,Hideo Matsuda,John S. Mattick,Stuart Meier,Sei Miyamoto,Etsuko Miyamoto-Sato,Kazuhiko Nakabayashi,Yutaka Nakachi,Mika Nakano,Sanne Nygaard,Toshitsugu Okayama,Yasushi Okazaki,Haruka Okuda-Yabukami,Valerio Orlando,Jun Otomo,Mikhail Pachkov,Nikolai Petrovsky,Charles Plessy,John Quackenbush,Aleksandar Radovanovic,Michael Rehli,Rintaro Saito,Albin Sandelin,Sebastian Schmeier,Christian Schönbach,Ariel S. Schwartz,Colin A. Semple,Miho Sera,Jessica Severin,Katsuhiko Shirahige,Cas Simons,Georges St. Laurent,Masanori Suzuki,Takahiro Suzuki,Matthew J. Sweet,Ryan J. Taft,Shizu Takeda,Yoichi Takenaka,Kai Tan,Martin S. Taylor,Rohan D. Teasdale,Jesper Tegnér,Jesper Tegnér,Sarah A. Teichmann,Eivind Valen,Claes Wahlestedt,Kazunori Waki,Andrew Waterhouse,Christine A. Wells,Ole Winther,Linda Wu,Kazumi Yamaguchi,Hiroshi Yanagawa,Jun Yasuda,Mihaela Zavolan,David A. Hume,Takahiro Arakawa,Shiro Fukuda,Kengo Imamura,Chikatoshi Kai,Ai Kaiho,Tsugumi Kawashima,Chika Kawazu,Yayoi Kitazume,Miki Kojima,Hisashi Miura,Kayoko Murakami,Mitsuyoshi Murata,Noriko Ninomiya,Hiromi Nishiyori,Shohei Noma,Chihiro Ogawa,Takuma Sano,Christophe Simon,Michihira Tagami,Yukari Takahashi,Jun Kawai,Yoshihide Hayashizaki +162 more
TL;DR: The results indicate that cellular states are constrained by complex networks involving both positive and negative regulatory interactions among substantial numbers of transcription factors and that no single transcription factor is both necessary and sufficient to drive the differentiation process.
Journal ArticleDOI
Cardiovascular anomaly, impaired actin bundling and resistance to Src-induced transformation in mice lacking p130Cas.
Hiroaki Honda,Hideaki Oda,Tetsuya Nakamoto,Zen-ichiro Honda,Ryuichi Sakai,Takahiro Suzuki,Toshiki Saito,Kenji Nakamura,Kazuki Nakao,Takatoshi Ishikawa,Motoya Katsuki,Yoshio Yazaki,Hisamaru Hirai +12 more
TL;DR: Findings have defined Cas function in cardiovascular development, actin filament assembly and Src-induced transformation in cells transformed by v-Src or v-Crk.
Journal ArticleDOI
Triple Transduction with Adeno-Associated Virus Vectors Expressing Tyrosine Hydroxylase, Aromatic-L-Amino-Acid Decarboxylase, and GTP Cyclohydrolase I for Gene Therapy of Parkinson's Disease
Yang Shen,Shin-ichi Muramatsu,Kunihiko Ikeguchi,Ken-ichi Fujimoto,Dong-Sheng Fan,Matsuo Ogawa,Hiroaki Mizukami,Masashi Urabe,Akihiro Kume,Ikuko Nagatsu,Fumi Urano,Takahiro Suzuki,Hiroshi Ichinose,Toshiharu Nagatsu,John Monahan,Imaharu Nakano,Keiya Ozawa +16 more
TL;DR: Results suggest that GCH, in addition to TH and AADC, is important for effective gene therapy of PD, and triple transduction enhanced BH4 and dopamine production in denervated striatum of parkinsonian rats and improved the rotational behavior of the rats more efficiently than did double transduction.
Journal ArticleDOI
Single-cell transcriptomics reveals expansion of cytotoxic CD4 T cells in supercentenarians.
Kosuke Hashimoto,Tsukasa Kouno,Tomokatsu Ikawa,Norihito Hayatsu,Yurina Miyajima,Haruka Yabukami,Tommy Terooatea,Takashi Sasaki,Takahiro Suzuki,Matthew Valentine,Giovanni Pascarella,Yasushi Okazaki,Harukazu Suzuki,Jay W. Shin,Aki Minoda,Ichiro Taniuchi,Hideyuki Okano,Yasumichi Arai,Nobuyoshi Hirose,Piero Carninci +19 more
TL;DR: The study reveals that supercentenarians have unique characteristics in their circulating lymphocytes, which may represent an essential adaptation to achieve exceptional longevity by sustaining immune responses to infections and diseases.