T
Takako Hishiki
Researcher at Keio University
Publications - 68
Citations - 3829
Takako Hishiki is an academic researcher from Keio University. The author has contributed to research in topics: Glycolysis & Cystathionine beta synthase. The author has an hindex of 28, co-authored 65 publications receiving 3088 citations. Previous affiliations of Takako Hishiki include Nagoya University.
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Journal ArticleDOI
Distinct metabolic flow enables large-scale purification of mouse and human pluripotent stem cell-derived cardiomyocytes.
Shugo Tohyama,Fumiyuki Hattori,Motoaki Sano,Takako Hishiki,Yoshiko Nagahata,Tomomi Matsuura,Hisayuki Hashimoto,Tomoyuki Suzuki,Hiromi Yamashita,Yusuke Satoh,Toru Egashira,Tomohisa Seki,Naoto Muraoka,Hiroyuki Yamakawa,Yasuyuki Ohgino,Tomofumi Tanaka,Masatoshi Yoichi,Shinsuke Yuasa,Mitsushige Murata,Makoto Suematsu,Keiichi Fukuda +20 more
TL;DR: A nongenetic method for mass-producing cardiomyocytes from mouse and human PSC derivatives that is based on the marked biochemical differences in glucose and lactate metabolism between cardiomers and noncardiomyocyte and could facilitate progress toward PSC-based cardiac regenerative therapy.
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Mitochondrial dysfunction associated with increased oxidative stress and α-synuclein accumulation in PARK2 iPSC-derived neurons and postmortem brain tissue.
Yoichi Imaizumi,Yohei Okada,Wado Akamatsu,Masato Koike,Naoko Kuzumaki,Hideki Hayakawa,Tomoko Nihira,Tetsuro Kobayashi,Manabu Ohyama,Shigeto Sato,Masashi Takanashi,Manabu Funayama,Akiyoshi Hirayama,Tomoyoshi Soga,Takako Hishiki,Makoto Suematsu,Takuya Yagi,Daisuke Ito,Arifumi Kosakai,Kozo Hayashi,Masanobu Shouji,Atsushi Nakanishi,Norihiro Suzuki,Yoshikuni Mizuno,Noboru Mizushima,Masayuki Amagai,Yasuo Uchiyama,Hideki Mochizuki,Hideki Mochizuki,Nobutaka Hattori,Hideyuki Okano +30 more
TL;DR: These novel findings reveal mechanistic insights into the onset of PARK2 and identify novel targets for drug screening and potential modified therapies for PD.
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Hypoxic regulation of the cerebral microcirculation is mediated by a carbon monoxide-sensitive hydrogen sulfide pathway
Takayuki Morikawa,Mayumi Kajimura,Tomomi Nakamura,Takako Hishiki,Tsuyoshi Nakanishi,Tsuyoshi Nakanishi,Yoshinori Yukutake,Yoshiko Nagahata,Mami Ishikawa,Katsuji Hattori,Toshiki Takenouchi,Takao Takahashi,Isao Ishii,Kazuko Matsubara,Yasuaki Kabe,Shinichiro Uchiyama,Eiichiro Nagata,Moataz M. Gadalla,Solomon H. Snyder,Makoto Suematsu +19 more
TL;DR: In intact adult brain cerebral cortex of HO-2–null mice, imaging mass spectrometry reveals an impaired ability to maintain ATP levels on hypoxia, and a pathway mediating Hypoxia-induced cerebral vasodilation is reported.
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Reduced methylation of PFKFB3 in cancer cells shunts glucose towards the pentose phosphate pathway
Takehiro Yamamoto,Naoharu Takano,Kyoko Ishiwata,Mitsuyo Ohmura,Yoshiko Nagahata,Tomomi Matsuura,Aki Kamata,Kyoko Sakamoto,Tsuyoshi Nakanishi,Akiko Kubo,Takako Hishiki,Makoto Suematsu +11 more
TL;DR: It is suggested that the CO/CBS-dependent regulation of PFKFB3 methylation determines directional glucose utilization to ensure resistance against oxidative stress for cancer cell survival.
Journal ArticleDOI
Glutamine Oxidation Is Indispensable for Survival of Human Pluripotent Stem Cells
Shugo Tohyama,Shugo Tohyama,Jun Fujita,Takako Hishiki,Tomomi Matsuura,Fumiyuki Hattori,Rei Ohno,Hideaki Kanazawa,Tomohisa Seki,Kazuaki Nakajima,Yoshikazu Kishino,Marina Okada,Akinori Hirano,Takuya Kuroda,Satoshi Yasuda,Yoji Sato,Shinsuke Yuasa,Motoaki Sano,Makoto Suematsu,Keiichi Fukuda +19 more
TL;DR: This distinguishing feature of hPSC metabolism allows preparation of clinical-grade cell sources free of undifferentiated hPSCs, which prevents tumor formation during stem cell therapy.