T
Takashi Kasai
Researcher at Kyoto Prefectural University of Medicine
Publications - 61
Citations - 2241
Takashi Kasai is an academic researcher from Kyoto Prefectural University of Medicine. The author has contributed to research in topics: Medicine & Biomarker (medicine). The author has an hindex of 20, co-authored 58 publications receiving 1878 citations. Previous affiliations of Takashi Kasai include Japan Agency for Medical Research and Development.
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Journal ArticleDOI
Detection of elevated levels of α-synuclein oligomers in CSF from patients with Parkinson disease
Takahiko Tokuda,Mohamed M. Qureshi,Mustafa T. Ardah,Shiji Varghese,Safa Shehab,Takashi Kasai,Noriko Ishigami,Akira Tamaoka,Masanori Nakagawa,Omar M. A. El-Agnaf +9 more
TL;DR: It is demonstrated that levels of α-synuclein oligomers in CSF and the oligomers/total-α- synuclein ratio can be useful biomarkers for diagnosis and early detection of PD.
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High-molecular-weight β-amyloid oligomers are elevated in cerebrospinal fluid of Alzheimer patients
Hiroaki Fukumoto,Takahiko Tokuda,Takashi Kasai,Noriko Ishigami,Hiroya Hidaka,Masaki Kondo,David Allsop,Masanori Nakagawa +7 more
TL;DR: The ELISAcould be useful as a diagnostic marker for AD, and also as a potential surrogate marker for disease severity, and the idea that soluble HMW Aβ oligomers play a critical role in the pathogenesis and progression of AD is supported.
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Quantification of plasma phosphorylated tau to use as a biomarker for brain Alzheimer pathology: pilot case-control studies including patients with Alzheimer's disease and down syndrome.
Harutsugu Tatebe,Takashi Kasai,Takuma Ohmichi,Yusuke Kishi,Tomoshi Kakeya,Masaaki Waragai,Masaki Kondo,David Allsop,Takahiko Tokuda +8 more
TL;DR: In this paper, the authors developed a novel ultrasensitive immunoassay to quantify plasma tau phosphorylated at threonine 181 (p-tau181) is informative in the diagnosis of AD.
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Increased TDP-43 protein in cerebrospinal fluid of patients with amyotrophic lateral sclerosis.
Takashi Kasai,Takahiko Tokuda,Noriko Ishigami,Hiroshi Sasayama,Penelope G. Foulds,Douglas J. Mitchell,David M. A. Mann,David Allsop,Masanori Nakagawa +8 more
TL;DR: Raised TDP-43 levels in the CSF may preempt the formation of T DP-43 pathology in the central nervous system, or correlate with early-stage TDP -43 pathology, and accordingly be a biomarker for the early stage of ALS.
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Cerebral white matter damage in frontotemporal dementia assessed by diffusion tensor tractography
Koushun Matsuo,Toshiki Mizuno,Kei Yamada,Kentaro Akazawa,Takashi Kasai,Masaki Kondo,Satoru Mori,Tsunehiko Nishimura,Masanori Nakagawa +8 more
TL;DR: The features of FTD from the view point of cerebral white matter damage were revealed by tractography based on DTI, and DTI is considered to be a useful method, and may provide clues to elucidating the pathogenesis ofFTD.