T
Takatsugu Mizumachi
Researcher at Hokkaido University
Publications - 72
Citations - 1237
Takatsugu Mizumachi is an academic researcher from Hokkaido University. The author has contributed to research in topics: Chemoradiotherapy & Cancer. The author has an hindex of 18, co-authored 70 publications receiving 1030 citations. Previous affiliations of Takatsugu Mizumachi include University of Arkansas for Medical Sciences.
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Journal ArticleDOI
Pretreatment lymphocyte‐to‐monocyte ratio as an independent prognostic factor for head and neck cancer
Satoshi Kano,Akihiro Homma,Hiromitsu Hatakeyama,Takatsugu Mizumachi,Tomohiro Sakashita,Tomohiko Kakizaki,Satoshi Fukuda +6 more
TL;DR: The purpose of this study was to analyze the relationship between pretreatment inflammatory markers and the prognosis of patients with oropharyngeal, hypopharyngeals, and laryngeAL cancers.
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Increased Distributional Variance of Mitochondrial DNA Content Associated With Prostate Cancer Cells as Compared With Normal Prostate Cells
Takatsugu Mizumachi,Levan Muskhelishvili,Akihiro Naito,Jun Furusawa,Chun-Yang Fan,Eric R. Siegel,Fred F. Kadlubar,Udaya Kumar,Masahiro Higuchi +8 more
TL;DR: Mitochondria are key organelles for apoptosis, and mitochondrial DNA content can regulate cancer progression, and increases in mtDNA mutations and deletions have been reported in cancer; however, a detailed investigation of mtDNA content in cancer cells has not yet been conducted.
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Concomitant weekly cisplatin and radiotherapy for head and neck cancer.
Akihiro Homma,Naoya Inamura,Nobuhiko Oridate,Seigo Suzuki,Hiromitsu Hatakeyama,Takatsugu Mizumachi,Satoshi Kano,Tomohiro Sakashita,Rikiya Onimaru,Koichi Yasuda,Hiroki Shirato,Satoshi Fukuda +11 more
TL;DR: This regimen appears to be a suitable alternative to three-weekly high-dose cisplatin with concomitant radiotherapy, because patients can be monitored more regularly for toxicity allowing the schedule to be altered if required.
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Progressive tumor features accompany epithelial-mesenchymal transition induced in mitochondrial DNA-depleted cells.
Akihiro Naito,Cody C. Cook,Takatsugu Mizumachi,Mian Wang,Cheng-Hui Xie,Teresa Evans,Thomas J. Kelly,Masahiro Higuchi +7 more
TL;DR: It is demonstrated that LNρ0‐8 and MCFρ0 have invasive characters as evaluated by the ability of invasion through the extracellular matrix (ECM) in vitro and the induction of vimentin and the repression of E‐cadherin expression in ρ0 cells indicate that they are mesenchymal cells.
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Mitochondrial regulation of cancer associated nuclear DNA methylation
Cheng-Hui Xie,Akihiro Naito,Takatsugu Mizumachi,Teresa Evans,Michael G. Douglas,Craig A. Cooney,Chun-Yang Fan,Masahiro Higuchi +7 more
TL;DR: It is found that mitochondrial DNA-deficient LNrho0-8 activates the hypermethylation of the nuclear DNA promoters including the promoter CpG islands of the endothelin B receptor, O6-methylguanine-DNA methyltransferase, and E-cadherin.