T
Takeo Yoshikawa
Researcher at Tohoku University
Publications - 101
Citations - 3013
Takeo Yoshikawa is an academic researcher from Tohoku University. The author has contributed to research in topics: Histamine & Histamine H1 receptor. The author has an hindex of 27, co-authored 101 publications receiving 2347 citations.
Papers
More filters
Journal ArticleDOI
18F-THK5351: A Novel PET Radiotracer for Imaging Neurofibrillary Pathology in Alzheimer Disease.
Ryuichi Harada,Nobuyuki Okamura,Shozo Furumoto,Katsutoshi Furukawa,Aiko Ishiki,Naoki Tomita,Tetsuro Tago,Kotaro Hiraoka,Shoichi Watanuki,Miho Shidahara,Masayasu Miyake,Yoichi Ishikawa,Rin Matsuda,Akie Inami,Takeo Yoshikawa,Yoshihito Funaki,Ren Iwata,Manabu Tashiro,Kazuhiko Yanai,Hiroyuki Arai,Yukitsuka Kudo +20 more
TL;DR: A novel tau PET tracer is developed through compound optimization of arylquinoline derivatives that bound to neurofibrillary tangles selectively and with a higher signal-to-background ratio than did THK5117 in Alzheimer disease patients.
Journal ArticleDOI
Novel 18F-labeled arylquinoline derivatives for noninvasive imaging of tau pathology in Alzheimer disease.
Nobuyuki Okamura,Shozo Furumoto,Ryuichi Harada,Tetsuro Tago,Takeo Yoshikawa,Michelle T. Fodero-Tavoletti,Rachel S. Mulligan,Victor L. Villemagne,Hiroyasu Akatsu,Takayuki Yamamoto,Hiroyuki Arai,Ren Iwata,Kazuhiko Yanai,Yukitsuka Kudo +13 more
TL;DR: Novel 18F-labeled arylquinoline derivatives are developed, which showed that these radiotracers preferentially bound to neurofibrillary tangles and neuropil threads, which colocalized with Gallyas-positive and immunoreactive tau protein deposits in AD brain sections.
Journal ArticleDOI
Comparative Analyses of Copy-Number Variation in Autism Spectrum Disorder and Schizophrenia Reveal Etiological Overlap and Biological Insights
Itaru Kushima,Branko Aleksic,Masahiro Nakatochi,Teppei Shimamura,Takashi Okada,Yota Uno,Yota Uno,Mako Morikawa,Kanako Ishizuka,Tomoko Shiino,Hiroki Kimura,Yuko Arioka,Akira Yoshimi,Yuto Takasaki,Yanjie Yu,Yukako Nakamura,Maeri Yamamoto,Tetsuya Iidaka,Shuji Iritani,Toshiya Inada,Nanayo Ogawa,Emiko Shishido,Youta Torii,Naoko Kawano,Yutaka Omura,Toru Yoshikawa,Tokio Uchiyama,Toshimichi Yamamoto,Masashi Ikeda,Ryota Hashimoto,Hidenaga Yamamori,Yuka Yasuda,Toshiyuki Someya,Yuichiro Watanabe,Jun Egawa,Ayako Nunokawa,Masanari Itokawa,Makoto Arai,Mitsuhiro Miyashita,Akiko Kobori,Michio Suzuki,Tsutomu Takahashi,Masahide Usami,Masaki Kodaira,Kyota Watanabe,Tsukasa Sasaki,Hitoshi Kuwabara,Mamoru Tochigi,Fumichika Nishimura,Hidenori Yamasue,Yosuke Eriguchi,Seico Benner,Masaki Kojima,Walid Yassin,Toshio Munesue,Shigeru Yokoyama,Ryo Kimura,Yasuko Funabiki,Hirotaka Kosaka,Makoto Ishitobi,Tetsuro Ohmori,Shusuke Numata,Takeo Yoshikawa,Tomoko Toyota,Kazuhiro Yamakawa,Toshimitsu Suzuki,Yushi Inoue,Kentaro Nakaoka,Yu-ichi Goto,Masumi Inagaki,Naoki Hashimoto,Ichiro Kusumi,Shuraku Son,Toshiya Murai,Tempei Ikegame,Naohiro Okada,Kiyoto Kasai,Shohko Kunimoto,Daisuke Mori,Nakao Iwata,Norio Ozaki +80 more
TL;DR: An etiological overlap of ASD and SCZ is suggested and multiple disease-relevant genes in eight well-known ASD/SCZ-associated CNV loci are identified, which provide biological insights into these disorders.
Journal ArticleDOI
The International Consortium on Lithium Genetics (ConLiGen): an initiative by the NIMH and IGSLI to study the genetic basis of response to lithium treatment.
Thomas G. Schulze,Martin Alda,Mazda Adli,Nirmala Akula,Raffaella Ardau,Elise T. Bui,Caterina Chillotti,Sven Cichon,Piotr M. Czerski,Maria Del Zompo,Sevilla D. Detera-Wadleigh,Paul Grof,Oliver Gruber,Ryota Hashimoto,Joanna Hauser,Rebecca Hoban,Rebecca Hoban,Nakao Iwata,Layla Kassem,Tadafumi Kato,Sarah Kittel-Schneider,Sebastian Kliwicki,John R. Kelsoe,John R. Kelsoe,Ichiro Kusumi,Gonzalo Laje,Susan G. Leckband,Susan G. Leckband,Susan G. Leckband,Mirko Manchia,Glenda MacQueen,Takuya Masui,Norio Ozaki,Roy H. Perlis,Andrea Pfennig,Paola Piccardi,Sara Richardson,Guy A. Rouleau,Andreas Reif,Janusz K. Rybakowski,Johanna Sasse,Johannes Schumacher,Johannes Schumacher,Giovanni Severino,Jordan W. Smoller,Alessio Squassina,Gustavo Turecki,L. Trevor Young,Takeo Yoshikawa,Michael Bauer,Francis J. McMahon +50 more
TL;DR: An international effort to elucidate the genetic underpinnings of lithium response in bipolar disorder is presented, currently comprising more than 1,200 patients characterized for response to lithium treatment.
Journal ArticleDOI
Correlations of 18F-THK5351 PET with Postmortem Burden of Tau and Astrogliosis in Alzheimer Disease.
Ryuichi Harada,Aiko Ishiki,Hideaki Kai,Naomi Sato,Katsutoshi Furukawa,Katsutoshi Furukawa,Shozo Furumoto,Tetsuro Tago,Naoki Tomita,Shoichi Watanuki,Kotaro Hiraoka,Yoichi Ishikawa,Yoshihito Funaki,Tadaho Nakamura,Takeo Yoshikawa,Ren Iwata,Manabu Tashiro,Hironobu Sasano,Tetsuyuki Kitamoto,Kazuhiko Yanai,Hiroyuki Arai,Yukitsuka Kudo,Nobuyuki Okamura,Nobuyuki Okamura +23 more
TL;DR: Regional in vivo 18F-THK5351 PET may have limited utility as a biomarker of tau pathology in AD; however, it could be used to monitor the neuroinflammatory processes in the living brain.