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Author

Takeru Higuchi

Bio: Takeru Higuchi is an academic researcher from University of Wisconsin-Madison. The author has contributed to research in topics: Aqueous solution & Solubility. The author has an hindex of 37, co-authored 206 publications receiving 11032 citations. Previous affiliations of Takeru Higuchi include Smith, Kline & French & Merck & Co..


Papers
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Journal ArticleDOI
TL;DR: The analyses suggest that for the latter system the time required to release 50% of the drug would normally be expected to be approximately 10 per cent of that required to dissolve the last trace of the solid drug phase in the center of the pellet.

4,383 citations

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TL;DR: An equation relating the rate of release of solid drugs suspended in ointment bases into perfect sinks is derived and the final expression is found to be surprisingly simple and convenient.

2,031 citations

Journal ArticleDOI
TL;DR: The results suggest that the tendency of many drugs to form such adducts provide pharmaceutical investigators a powerful tool in effecting rapid dissolution of highly insoluble substances.

355 citations

Journal ArticleDOI
TL;DR: The thermodynamic relationships involving polymorphism and solubility were examined in some detail and applied to experimental results with the methylprednisolone system and indicate that much more energetic crystal forms are probable.

199 citations


Cited by
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Journal ArticleDOI
TL;DR: Drug dissolution from solid dosage forms has been described by kinetic models in which the dissolved amount of drug (Q) is a function of the test time, t or Q=f(t).

4,794 citations

Book
16 Dec 1999
TL;DR: Overview of membrane science and technology membrane transport theory membrane and modules concentration polarization reverse osmosis ultrafiltration microfiltration gas separation pervaporation ion exchange membrane processes - electrodialysis carrier facilitated transport medical applications of membranes other membranes processed.
Abstract: Overview of membrane science and technology membrane transport theory membrane and modules concentration polarization reverse osmosis ultrafiltration microfiltration gas separation pervaporation ion exchange membrane processes - electrodialysis carrier facilitated transport medical applications of membranes other membranes processed.

3,680 citations

Journal ArticleDOI
TL;DR: In this paper, a simple exponential relation Mt/M∞ = ktn is introduced to describe the general solute release behavior of controlled release polymeric devices, where Mt is the fractional release, t is the release time, k is a constant, and n is the diffusional exponent characteristic of the release mechanism.

3,256 citations

Journal ArticleDOI
TL;DR: The present article is a comprehensive review of the current state of the art of mathematical modeling drug release from HPMC-based delivery systems and discusses the crucial points of the most important theories.

2,354 citations

Journal ArticleDOI
TL;DR: The present review outlines the major new findings on the pharmaceutical applications of chitosan-based micro/nanoparticulate drug delivery systems published over the past decade and discusses critically the usefulness of these systems in delivering the bioactive molecules.

2,314 citations