T
Takeshi Sakaba
Researcher at Doshisha University
Publications - 56
Citations - 4806
Takeshi Sakaba is an academic researcher from Doshisha University. The author has contributed to research in topics: Synaptic vesicle & Neurotransmission. The author has an hindex of 29, co-authored 50 publications receiving 4379 citations. Previous affiliations of Takeshi Sakaba include University of Tokyo & Max Planck Society.
Papers
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Journal ArticleDOI
Multiple roles of calcium ions in the regulation of neurotransmitter release.
Erwin Neher,Takeshi Sakaba +1 more
TL;DR: Two distinct roles of [Ca(2+)] are proposed in vesicle recruitment: one accelerating "molecular priming" (vesicle docking and the buildup of a release machinery), the other promoting the tight coupling between releasable vesicles and Ca(2+) channels.
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Calmodulin mediates rapid recruitment of fast-releasing synaptic vesicles at a calyx-type synapse.
Takeshi Sakaba,Erwin Neher +1 more
TL;DR: It is proposed that calmodulin-dependent refilling supports recovery from synaptic depression during high-frequency trains in concert with rapid recovery of the slowly releasing vesicles.
Journal ArticleDOI
Vesicle pools and short-term synaptic depression: lessons from a large synapse
TL;DR: By influencing the synaptic output during repetitive activity, vesicle pool dynamics are expected to modulate information processing in neuronal networks of the CNS.
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Direct modulation of synaptic vesicle priming by GABA B receptor activation at a glutamatergic synapse
Takeshi Sakaba,Erwin Neher +1 more
TL;DR: The differential modulation of the two forms of synaptic plasticity, presynaptic inhibition and calcium-dependent recovery from synaptic depression, is expected to have interesting consequences for the dynamic behaviour of neural networks.
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The coupling between synaptic vesicles and Ca2+ channels determines fast neurotransmitter release
TL;DR: It is concluded that recruitment of synaptic vesicles to sites where Ca2+ channels cluster, rather than fusion competence, is a limiting step for rapid neurotransmitter release in response to presynaptic action potentials.