T
Takuma Sasaki
Researcher at Hokkaido University
Publications - 96
Citations - 3068
Takuma Sasaki is an academic researcher from Hokkaido University. The author has contributed to research in topics: Nucleotide & Nucleic acid. The author has an hindex of 34, co-authored 96 publications receiving 2982 citations. Previous affiliations of Takuma Sasaki include National Cancer Research Institute & Kanazawa University.
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Purealidins B and C, new bromotyrosine alkaloids from the okinawan marine sponge psammaplysilla purea
Jun'ichi Kobayashi,Masashi Tsuda,Kaori Agemi,Hideyuki Shigemori,Masami Ishibashi,Takuma Sasaki,Takuma Sasaki,Yuzuru Mikami,Yuzuru Mikami +8 more
TL;DR: In this paper, bromotyrosine-derived alkaloids, purealidins B (1) and C (2), have been isolated from the Okinawan marine sponge Psammaplysilla purea and their structures elucidated on the basis of spectroscopic data.
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Alteramide A, a new tetracyclic alkaloid from a bacterium Alteromonas sp. associated with the marine sponge Halichondria okadai
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Ascididemin, a novel pentacyclic aromatic alkaloid with potent antileukemic activity from the Okinawan tunicate Didemnum sp.
Jun'ichi Kobayash,Jie-fei Cheng,Hideshi Nakamura,Yasushi Ohizumi,Yoshimasa Hirata,Takuma Sasaki,Tomihisa Ohta,Shigeo Nozoe +7 more
TL;DR: A pentacyclic aromatic alkaloid, ascididemin (1), with potent antineoplastic activity has been isolated from the Okinawan tunicate Didemnum sp..
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Nucleosides and nucleotides. 158. 1-(3-C-ethynyl-beta-D-ribo-pentofuranosyl)-cytosine, 1-(3-C-ethynyl-beta-D-ribo-pentofuranosyl)uracil, and their nucleobase analogues as new potential multifunctional antitumor nucleosides with a broad spectrum of activity.
TL;DR: In vitro tumor cell growth inhibitory activity of these 3‘-C-ethynyl nucleoside nucleosides against mouse leukemia L1210 and human nasopharyngeal KB cells showed that 1-(3- C-ethnyl-β-d-ribo-pentofuranosyl)cytosine (ECyd) and EUrd were the most potent inhibitors in the series.
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Nucleosides and nucleotides. 185. Synthesis and biological activities of 4'alpha-C-branched-chain sugar pyrimidine nucleosides.
Makoto Nomura,Satoshi Shuto,Motohiro Tanaka,Takuma Sasaki,Shuichi Mori,Shiro Shigeta,Akira Matsuda +6 more
TL;DR: Almost all of the nucleosides showed anti-HIV-1 activities, they were also cytotoxic to the host cells (MT-4) and antiviral activities against HSV-1,HSV-2, and HIV-1 in vitro were examined.