Author
Tamires Cardoso Lima
Bio: Tamires Cardoso Lima is an academic researcher from Universidade Federal de Sergipe. The author has contributed to research in topics: Anticonvulsant & Perillyl alcohol. The author has an hindex of 13, co-authored 29 publications receiving 581 citations.
Papers
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TL;DR: In this review the antitumor activity of 37 monoterpenes found in essential oils is discussed and chemical structures, experimental models, and mechanisms of action for bioactive substances are presented.
Abstract: Cancer is a complex genetic disease that is a major public health problem worldwide, accounting for about 7 million deaths each year. Many anticancer drugs currently used clinically have been isolated from plant species or are based on such substances. Accumulating data has revealed anticancer activity in plant-derived monoterpenes. In this review the antitumor activity of 37 monoterpenes found in essential oils is discussed. Chemical structures, experimental models, and mechanisms of action for bioactive substances are presented.
192 citations
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TL;DR: The chemical and pharmacological perspectives related to the discovery of flavonoids with antidepressant activity are summarized and the mechanisms of action of these compounds are discussed, including their actions on oxidative stress relating to depression.
Abstract: Depression is a serious disorder that affects hundreds of millions of people around the world and causes poor quality of life, problem behaviors, and limitations in activities of daily living. Therefore, the search for new therapeutic options is of high interest and growth. Research on the relationship between depression and oxidative stress has shown important biochemical aspects in the development of this disease. Flavonoids are a class of natural products that exhibit several pharmacological properties, including antidepressant-like activity, and affects various physiological and biochemical functions in the body. Studies show the clinical potential of antioxidant flavonoids in treating depressive disorders and strongly suggest that these natural products are interesting prototype compounds in the study of new antidepressant drugs. So, this review will summarize the chemical and pharmacological perspectives related to the discovery of flavonoids with antidepressant activity. The mechanisms of action of these compounds are also discussed, including their actions on oxidative stress relating to depression.
78 citations
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TL;DR: The results from the present study showed that the MVEO exhibited outstanding toxic effects against Ae.
57 citations
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TL;DR: This review reports on the current studies of essential oils’ chemical constituents with analgesic-like activity, including a description of their mechanisms of action and chemical aspects.
Abstract: The constituents of essential oils are widely found in foods and aromatic plants giving characteristic odor and flavor. However, pharmacological studies evidence its therapeutic potential for the treatment of several diseases and promising use as compounds with analgesic-like action. Considering that pain affects a significant part of the world population and the need for the development of new analgesics, this review reports on the current studies of essential oils’ chemical constituents with analgesic-like activity, including a description of their mechanisms of action and chemical aspects.
55 citations
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TL;DR: The results, along with the low toxicity of the (+)-limonene epoxide, suggest that this natural compound might be promising for the development of new schistosomicidal agents.
Abstract: Blood fluke of the genus Schistosoma are the etiological agents of
human schistosomiasis, an important neglected tropical disease that afflicts
over 200 million people worldwide. The treatment for this disease relies
heavily on a single drug, praziquantel. Recent reports of praziquantel
resistance raise concerns about future control of the disease and show the
importance of developing new antischistosomal drugs. Currently, natural
products have been a good source for drug development. (+)-Limonene epoxide
is a mixture of cis and trans isomers found in many plants.
Here, we report the in vitro effect of this natural compound on the
survival time of Schistosoma mansoni adult worms. In addition, we
examined alterations on the tegumental surface of adult schistosomes by
means of confocal laser scanning microscopy. The effects of (+)-limonene
epoxide at 25 µg/mL on S. mansoni adult worms were similar to those
of the positive control (praziquantel), with reduction in motility and death
of all worms after 120 h. Confocal laser scanning microscopy revealed that
(+)-limonene epoxide-mediated worm killing was associated with tegumental
destruction. Our results, along with the low toxicity of the (+)-limonene
epoxide, suggest that this natural compound might be promising for the
development of new schistosomicidal agents.
47 citations
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01 Jan 2010
TL;DR: The Oleo-gum-resin exuded by this tree has been regarded as a sovereign remedy in ancient medicine and has marked antiseptic properties.
Abstract: Balsamodendron mukul (Guggul): The Oleo-gum-resin exuded by this tree has been regarded as a sovereign remedy in ancient medicine. It is a bitter stomachic and carminative and improves digestion. It is quickly absorbed and is excreted by skin, mucous membranes and kidneys and in the course of excretion it disinfects their secretions improves the function and stimulates the activity of the respective organs. It has marked antiseptic properties.
411 citations
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TL;DR: A deeper involvement of phytocannabinoids (the key compounds in C. sativa) in several others central and peripheral pathophysiological mechanisms such as food intake, inflammation, pain, colitis, sleep disorders, neurological and psychiatric illness is suggested.
315 citations
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TL;DR: Selenium nanoparticles can open ways to new regular strategies for treating illnesses like malignancy, and this audit expresses the reasons why these nano measured medications can be the following huge achievement as chemotherapeutic operators.
273 citations
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TL;DR: Pre-clinical and clinical studies with some selected Brazilian medicinal plants in different areas of interest, conducted by research groups in Brazil and abroad are focused on, highlighting the Brazilian market of herbal products and the efforts of Brazilian scientists to develop new phytomedicines.
271 citations
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12 Nov 2019TL;DR: This chapter summarizes the various terpenes, their sources, medicinal properties, mechanism of action, and the recent studies that are underway for designing terpene as a lead molecule in the modern medicine.
Abstract: Terpenes, also known as terpenoids are the largest and most diverse group of naturally occurring compounds. Based on the number of isoprene units they have, they are classified as mono, di, tri, tetra, and sesquiterpenes. They are mostly found in plants and form the major constituent of essential oils from plants. Among the natural products that provide medical benefits for an organism, terpenes play a major and variety of roles. The common plant sources of terpenes are tea, thyme, cannabis, Spanish sage, and citrus fruits (e.g., lemon, orange, mandarin). Terpenes have a wide range of medicinal uses among which antiplasmodial activity is notable as its mechanism of action is similar to the popular antimalarial drug in use—chloroquine. Monoterpenes specifically are widely studied for their antiviral property. With growing incidents of cancer and diabetes in modern world, terpenes also have the potential to serve as anticancer and antidiabetic reagents. Along with these properties, terpenes also allow for flexibility in route of administration and suppression of side effects. Certain terpenes were widely used in natural folk medicine. One such terpene is curcumin which holds anti-inflammatory, antioxidant, anticancer, antiseptic, antiplasmodial, astringent, digestive, diuretic, and many other properties. Curcumin has also become a recent trend in healthy foods and open doors for several medical researches. This chapter summarizes the various terpenes, their sources, medicinal properties, mechanism of action, and the recent studies that are underway for designing terpenes as a lead molecule in the modern medicine.
192 citations