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Author

Tanmoy Bera

Other affiliations: Indian Oil Corporation
Bio: Tanmoy Bera is an academic researcher from Jadavpur University. The author has contributed to research in topics: Electron transport chain & Leishmania donovani. The author has an hindex of 17, co-authored 45 publications receiving 829 citations. Previous affiliations of Tanmoy Bera include Indian Oil Corporation.


Papers
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Journal ArticleDOI
TL;DR: New quercetin conjugated gold nanoparticles (QAunp) were successfully evaluated for the first time against leishmanial macrophage infections.

104 citations

Journal ArticleDOI
TL;DR: Antileishmanial activity was found to be significant for the nanoparticle preparation with 4% PVA in about one-fourth of the dosage of the pure compound AG (IC50 160 μM), which have significant potential to target the infested macrophage cells and prove valuable in chemotherapy of neglected tropical diseases such as leishmaniasis.
Abstract: Andrographolide (AG) is a diterpenoid lactone isolated from the leaves of Andrographis paniculata. AG is a potent and low-toxicity antileishmanial agent. Chemotherapy applications of AG are, however, seriously constrained because of poor bioavailability, short plasma half-life, and inappropriate tissue localization. Nanoparticulation of AG was therefore envisaged as a possible solution. AG nanoparticles (AGnp) loaded in 50:50 poly(DL-lactide-co-glycolic acid) were prepared for delivery into the monocyte-macrophage cells infested with the amastigote form of leishmanial parasite for evaluation in the chemotherapy of leishmaniasis. Particle characteristics of AGnp were optimized by proportionate application of a stabilizer, polyvinyl alcohol (PVA). Physicochemical characterization of AGnp by photon correlation spectroscopy exhibited an average particle size of 173 nm and zeta potential of -34.8 mV. Atomic force microscopy visualization revealed spherical nanoparticles with a smooth surface. Antileishmanial activity was found to be significant for the nanoparticle preparation with 4% PVA (IC₅₀) 34 μM) in about one-fourth of the dosage of the pure compound AG (IC₅₀) 160 μM). AGnp therefore have significant potential to target the infested macrophage cells and prove valuable in chemotherapy of neglected tropical diseases such as leishmaniasis.

78 citations

Journal ArticleDOI
TL;DR: Analyses of the up-regulated genes that are associated with stress response, viz., signal transduction, tissue destruction, and oxidative stress management, including enhanced expression of a 29-kDa Eh29, suggest that this organism has several protective mechanisms to deal with oxidative stress during invasion.

71 citations

Book
22 Jul 2015
TL;DR: Modern Applications of Plant Biotechnology in Pharmaceutical Sciences explores advanced techniques in plant biotechnology, their applications to pharmaceutical sciences, and how these methods can lead to more effective, safe, and affordable drugs.
Abstract: Modern Applications of Plant Biotechnology in Pharmaceutical Sciences explores advanced techniques in plant biotechnology, their applications to pharmaceutical sciences, and how these methods can lead to more effective, safe, and affordable drugs. The book covers modern approaches in a practical, step-by-step manner, and includes illustrations, examples, and case studies to enhance understanding. Key topics include plant-made pharmaceuticals, classical and non-classical techniques for secondary metabolite production in plant cell culture and their relevance to pharmaceutical science, edible vaccines, novel delivery systems for plant-based products, international industry regulatory guidelines, and more. Readers will find the book to be a comprehensive and valuable resource for the study of modern plant biotechnology approaches and their pharmaceutical applications.Builds upon the basic concepts of cell and plant tissue culture and recombinant DNA technology to better illustrate the modern and potential applications of plant biotechnology to the pharmaceutical sciencesProvides detailed yet practical coverage of complex techniques, such as micropropogation, gene transfer, and biosynthesisExamines critical issues of international importance and offers real-life examples and potential solutions

67 citations

Journal ArticleDOI
TL;DR: The results indicated that P. vietnamenis possesses potential immunomodulatory activity and has therapeutic potential for the prevention of autoimmune diseases.

62 citations


Cited by
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Journal Article
TL;DR: This is a paid internship where interns work directly to assist the Director of Marketing and Communications on various tasks relating to upcoming GRA events.
Abstract: OVERVIEW The GRA Marketing Internship Program is offered to students who are interested in gaining valuable work experience through efforts in marketing, membership, sales, and events. Interns work directly to assist the Director of Marketing and Communications on various tasks relating to upcoming GRA events. During this internship, students will work a minimum of 10 hours a week and a maximum of 20 hours a week. Students are encouraged to earn credit for their internship, however this is a paid internship. Students interested in obtaining credit for their internship must consult their academic advisor or the intern coordinator at their academic unit.

1,309 citations

Journal ArticleDOI
TL;DR: This review introduces basic immunological concepts required to understand the mechanisms that rule the potential claimed immunostimulatory activity of polysaccharides and critically presents a literature survey on the structural features of the poly Saccharide and reported immunostIMulatory activity.

664 citations

Journal ArticleDOI
TL;DR: Biosynthetic pathway of isoprenoid quinones has been described, as well as their additional, recently recognized, diverse functions in bacterial, plant and animal metabolism.

396 citations

Journal ArticleDOI
TL;DR: In this article, a review has focused on the various plant-mediated nanoparticle fabrication approaches, with brief discussions on the categories of various plant mediated synthesis approaches and mechanistic aspects of plant mediated nanoparticle synthesis.
Abstract: In recent years, the progress of efficient green chemistry approaches for the fabrication of commercially viable noble metallic nanoparticles has become a major focus of researchers. The present review has focused on the various plant-mediated nanoparticle fabrication approaches, with brief discussions on the categories of various plant-mediated synthesis approaches and mechanistic aspects of plant-mediated nanoparticle synthesis. The review also focused on the commercial applications of plant-mediated noble metal nanoparticles. Significant remarks on the limitations of plant-mediated fabrication approaches with prospective future direction are also examined.

298 citations

Journal ArticleDOI
TL;DR: A thorough understanding of the mechanisms of green synthesis and high-throughput screening of stabilizing/capping agents on the physico-chemical properties of GNPs is warranted to realize the full potential of green nanotechnology.
Abstract: The ability of organisms and organic compounds to reduce metal ions and stabilize them into nanoparticles (NPs) forms the basis of green synthesis. To date, synthesis of NPs from various metal ions using a diverse array of plant extracts has been reported. However, a clear understanding of the mechanism of green synthesis of NPs is lacking. Although most studies have neglected to analyze the green-synthesized NPs (GNPs) for the presence of compounds derived from the extract, several studies have demonstrated the conjugation of sugars, secondary metabolites, and proteins in these biogenic NPs. Despite several reports on the bioactivities (antimicrobial, antioxidant, cytotoxic, catalytic, etc.) of GNPs, only a handful of studies have compared these activities with their chemically synthesized counterparts. These comparisons have demonstrated that GNPs possess better bioactivities than NPs synthesized by other methods, which might be attributed to the presence of plant-derived compounds in these NPs. The ability of NPs to bind with organic compounds to form a stable complex has huge potential in the harvesting of precious molecules and for drug discovery, if harnessed meticulously. A thorough understanding of the mechanisms of green synthesis and high-throughput screening of stabilizing/capping agents on the physico-chemical properties of GNPs is warranted to realize the full potential of green nanotechnology.

274 citations