T
Tao Cai
Publications - 2
Citations - 3621
Tao Cai is an academic researcher. The author has contributed to research in topics: Enhancer & Innate immune system. The author has an hindex of 2, co-authored 2 publications receiving 2080 citations.
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Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death
Jianjin Shi,Yue Zhao,Kun Wang,Xuyan Shi,Wang Yue,Huanwei Huang,Yinghua Zhuang,Tao Cai,Fengchao Wang,Feng Shao +9 more
TL;DR: Gasdermin D (Gsdmd) is identified by genome-wide clustered regularly interspaced palindromic repeat-Cas9 nuclease screens of caspase-11- and caspasing-1-mediated pyroptosis in mouse bone marrow macrophages to offer insight into inflammasome-mediated immunity/diseases and change the understanding of pyroPTosis and programmed necrosis.
Journal ArticleDOI
SET-domain bacterial effectors target heterochromatin protein 1 to activate host rDNA transcription
TL;DR: It is shown that LegAS4, a Legionella pneumophila type IV secretion system (TFSS) effector, is targeted to specific rDNA chromatin regions in the host nucleolus, contributing to infection‐induced rDNA transcription and bacterial intracellular replication.