T
Tao Zheng
Researcher at Johns Hopkins University School of Medicine
Publications - 60
Citations - 6547
Tao Zheng is an academic researcher from Johns Hopkins University School of Medicine. The author has contributed to research in topics: Inflammation & Cytokine. The author has an hindex of 34, co-authored 51 publications receiving 6062 citations. Previous affiliations of Tao Zheng include Yale University.
Papers
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Journal ArticleDOI
Acidic Mammalian Chitinase in Asthmatic Th2 Inflammation and IL-13 Pathway Activation
Zhou Zhu,Tao Zheng,Robert J. Homer,Yoon Keun Kim,Ning Yuan Chen,Lauren Cohn,Qutayba Hamid,Jack A. Elias +7 more
TL;DR: It is shown that acidic mammalian chitinase (AMCase) is induced via a T helper-2 (Th2)–specific, interleukin-13 (IL-13)–mediated pathway in epithelial cells and macrophages in an aeroallergen asthma model and expressed in exaggerated quantities in human asthma.
Journal ArticleDOI
Inducible targeting of IL-13 to the adult lung causes matrix metalloproteinase– and cathepsin-dependent emphysema
Tao Zheng,Zhou Zhu,Zhongde Wang,Robert J. Homer,Robert J. Homer,Bing Ma,Richard J. Riese,Harold A. Chapman,Steven D. Shapiro,Jack A. Elias +9 more
TL;DR: It is demonstrated that IL-13 is a potent stimulator of MMP and cathepsin-based proteolytic pathways in the lung and causes emphysema with enhanced lung volumes and compliance, mucus metaplasia, and inflammation, when inducibly overexpressed in the adult murine lung.
Journal ArticleDOI
The Atopic March: Progression from Atopic Dermatitis to Allergic Rhinitis and Asthma.
TL;DR: Recent studies support the idea of a causal link between AD and later onset atopic disorders and suggest that a dysfunctional skin barrier serves as a site for allergic sensitization to antigen and colonization of bacterial super antigens.
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New insights into the pathogenesis of asthma
TL;DR: It is reasonable to think of asthma as a pul-monary disorder characterized by the generalized reversible obstruction of airflow and to define reversibility as a greater than 12% increase in the patient’s forced expiratory volume in 1 second.
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Interferon γ induction of pulmonary emphysema in the adult murine lung
Zhongde Wang,Tao Zheng,Zhou Zhu,Robert J. Homer,Richard J. Riese,Harold A. Chapman,Steven D. Shapiro,Jack A. Elias +7 more
TL;DR: It is demonstrated that interferon γ (IFN-γ), a prominent product of CD8+ cells, causes emphysema with alveolar enlargement, enhanced lung volumes, enhanced pulmonary compliance, and macrophage- and neutrophil-rich inflammation when inducibly targeted to the adult murine lung.