Taowei David Wang

Bio: Taowei David Wang is an academic researcher from University of Maryland, College Park. The author has contributed to research in topics: Information visualization & Visual analytics. The author has an hindex of 10, co-authored 11 publications receiving 1031 citations. Previous affiliations of Taowei David Wang include Partners HealthCare.

LifeFlow: visualizing an overview of event sequences

Abstract: Event sequence analysis is an important task in many domains: medical researchers may study the patterns of transfers within the hospital for quality control; transportation experts may study accident response logs to identify best practices. In many cases they deal with thousands of records. While previous research has focused on searching and browsing, overview tasks are often overlooked. We introduce a novel interactive visual overview of event sequences called \emph{LifeFlow}. LifeFlow is scalable, can summarize all possible sequences, and represents the temporal spacing of the events within sequences. Two case studies with healthcare and transportation domain experts are presented to illustrate the usefulness of LifeFlow. A user study with ten participants confirmed that after 15 minutes of training novice users were able to rapidly answer questions about the prevalence and temporal characteristics of sequences, find anomalies, and gain significant insight from the data.

Aligning temporal data by sentinel events: discovering patterns in electronic health records

Abstract: Electronic Health Records (EHRs) and other temporal databases contain hidden patterns that reveal important cause-and-effect phenomena. Finding these patterns is a challenge when using traditional query languages and tabular displays. We present an interactive visual tool that complements query formulation by providing operations to align, rank and filter the results, and to visualize estimates of the intervals of validity of the data. Display of patient histories aligned on sentinel events (such as a first heart attack) enables users to spot precursor, co-occurring, and aftereffect events. A controlled study demonstrates the benefits of providing alignment (with a 61% speed improvement for complex tasks). A qualitative study and interviews with medical professionals demonstrates that the interface can be learned quickly and seems to address their needs.

Interactive Information Visualization to Explore and Query Electronic Health Records

Abstract: Physicians are confronted with increasingly complex patient histories based on which they must make life-critical treatment decisions. At the same time, clinical researchers are eager to study the growing databases of patient histories to detect unknown patterns, ensure quality control, and discover surprising outcomes. Designers of Electronic Health Record systems (EHRs) have great potential to apply innovative visual methods to support clinical decision-making and research. This work surveys the state-of-the-art of information visualization systems for exploring and querying EHRs, as described in the scientific literature. We examine how systems differ in their features and highlight how these differences are related to their design and the medical scenarios they tackle. The systems are compared on a set of criteria: (1) data types covered, (2) multivariate analysis support, (3) number of patient records used (one or multiple), and (4) user intents addressed. Based on our survey and evidence gained from evaluation studies, we believe that effective information visualization can facilitate analysis of EHRs for patient treatment and clinical research. Thus, we encourage the information visualization community to study the application of their systems in health care. Our monograph is written for both scientific researchers and designers of future user interfaces for EHRs. We hope it will help them understand this vital domain and appreciate the features and virtues of existing systems, so they can create still more advanced systems. We identify potential future research topics in interactive support for data abstraction, in systems for intermittent users, such as patients, and in more detailed evaluations.

Temporal Summaries: Supporting Temporal Categorical Searching, Aggregation and Comparison

Abstract: When analyzing thousands of event histories, analysts often want to see the events as an aggregate to detect insights and generate new hypotheses about the data. An analysis tool must emphasize both the prevalence and the temporal ordering of these events. Additionally, the analysis tool must also support flexible comparisons to allow analysts to gather visual evidence. In a previous work, we introduced align, rank, and filter (ARF) to accentuate temporal ordering. In this paper, we present temporal summaries, an interactive visualization technique that highlights the prevalence of event occurrences. Temporal summaries dynamically aggregate events in multiple granularities (year, month, week, day, hour, etc.) for the purpose of spotting trends over time and comparing several groups of records. They provide affordances for analysts to perform temporal range filters. We demonstrate the applicability of this approach in two extensive case studies with analysts who applied temporal summaries to search, filter, and look for patterns in electronic health records and academic records.

Extracting Insights from Electronic Health Records: Case Studies, a Visual Analytics Process Model, and Design Recommendations

Abstract: Current electronic health record (EHR) systems facilitate the storage, retrieval, persistence, and sharing of patient data. However, the way physicians interact with EHRs has not changed much. More specifically, support for temporal analysis of a large number of EHRs has been lacking. A number of information visualization techniques have been proposed to alleviate this problem. Unfortunately, due to their limited application to a single case study, the results are often difficult to generalize across medical scenarios. We present the usage data of Lifelines2 (Wang et al. 2008), our information visualization system, and user comments, both collected over eight different medical case studies. We generalize our experience into a visual analytics process model for multiple EHRs. Based on our analysis, we make seven design recommendations to information visualization tools to explore EHR systems.

Exploratory Search:Beyond the Query-Response Paradigm

Abstract: As information becomes more ubiquitous and the demands that searchers have on search systems grow, there is a need to support search behaviors beyond simple lookup. Information seeking is the process or activity of attempting to obtain information in both human and technological contexts. Exploratory search describes an information-seeking problem context that is open-ended, persistent, and multifaceted, and information-seeking processes that are opportunistic, iterative, and multitactical. Exploratory searchers aim to solve complex problems and develop enhanced mental capacities. Exploratory search systems support this through symbiotic human-machine relationships that provide guidance in exploring unfamiliar information landscapes. Exploratory search has gained prominence in recent years. There is an increased interest from the information retrieval, information science, and human-computer interaction communities in moving beyond the traditional turn-taking interaction model support d by major Web search engines, and toward support for human intelligence amplification and information use. In this lecture, we introduce exploratory search, relate it to relevant extant research, outline the features of exploratory search systems, discuss the evaluation of these systems, and suggest some future directions for supporting exploratory search. Exploratory search is a new frontier in the search domain and is becoming increasingly important in shaping our future world. Table of Contents: Introduction / Defining Exploratory Search / Related Work / Features of Exploratory Search Systems / Evaluation of Exploratory Search Systems / Future Directions and concluding Remarks

Polygenic prediction via Bayesian regression and continuous shrinkage priors.

Abstract: Polygenic risk scores (PRS) have shown promise in predicting human complex traits and diseases. Here, we present PRS-CS, a polygenic prediction method that infers posterior effect sizes of single nucleotide polymorphisms (SNPs) using genome-wide association summary statistics and an external linkage disequilibrium (LD) reference panel. PRS-CS utilizes a high-dimensional Bayesian regression framework, and is distinct from previous work by placing a continuous shrinkage (CS) prior on SNP effect sizes, which is robust to varying genetic architectures, provides substantial computational advantages, and enables multivariate modeling of local LD patterns. Simulation studies using data from the UK Biobank show that PRS-CS outperforms existing methods across a wide range of genetic architectures, especially when the training sample size is large. We apply PRS-CS to predict six common complex diseases and six quantitative traits in the Partners HealthCare Biobank, and further demonstrate the improvement of PRS-CS in prediction accuracy over alternative methods.

Increased synapse elimination by microglia in schizophrenia patient-derived models of synaptic pruning.

Abstract: Synapse density is reduced in postmortem cortical tissue from schizophrenia patients, which is suggestive of increased synapse elimination. Using a reprogrammed in vitro model of microglia-mediated synapse engulfment, we demonstrate increased synapse elimination in patient-derived neural cultures and isolated synaptosomes. This excessive synaptic pruning reflects abnormalities in both microglia-like cells and synaptic structures. Further, we find that schizophrenia risk-associated variants within the human complement component 4 locus are associated with increased neuronal complement deposition and synapse uptake; however, they do not fully explain the observed increase in synapse uptake. Finally, we demonstrate that the antibiotic minocycline reduces microglia-mediated synapse uptake in vitro and its use is associated with a modest decrease in incident schizophrenia risk compared to other antibiotics in a cohort of young adults drawn from electronic health records. These findings point to excessive pruning as a potential target for delaying or preventing the onset of schizophrenia in high-risk individuals.

A Review of 25 Years of CSCW Research in Healthcare: Contributions, Challenges and Future Agendas

Abstract: CSCW as a field has been concerned since its early days with healthcare, studying how healthcare work is collaboratively and practically achieved and designing systems to support that work. Reviewing literature from the CSCW Journal and related conferences where CSCW work is published, we reflect on the contributions that have emerged from this work. The analysis illustrates a rich range of concepts and findings towards understanding the work of healthcare but the work on the larger policy level is lacking. We argue that this presents a number of challenges for CSCW research moving forward: in having a greater impact on larger-scale health IT projects; broadening the scope of settings and perspectives that are studied; and reflecting on the relevance of the traditional methods in this field - namely workplace studies - to meet these challenges.