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Tapan Kumar Mandal

Bio: Tapan Kumar Mandal is an academic researcher from Jadavpur University. The author has contributed to research in topics: Crystal structure & Denticity. The author has an hindex of 1, co-authored 1 publications receiving 7 citations.

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Journal ArticleDOI
TL;DR: In this article, a few dioxomolybdenum complexes of the type MoO2L and MoVIO2L of a new diprotic tridentate ONS chelating ligand, H2L, have been synthesized with the aim to examine their potential to behave as models for the active site of an oxidoreductase molybdoenzyme like xanthineoxidase.

12 citations

Journal ArticleDOI
TL;DR: Cd(II), Cu(II, and Ni(II) complexes based on 2-(2-pyridyl)benzothiazole were synthesized and the crystal structures of complexes 1-3 were determined by single-crystal X-ray diffraction analyses as discussed by the authors.

11 citations

Journal ArticleDOI
TL;DR: Two mononuclear ruthenium(iii) mer- and fac-isomers of the formula [RuCl3(PPh3)(dmpbt)] have been synthesised from the reaction of a bidentate ligand - dmpbt with the ability to induce apoptosis and the crystal and molecular structures were determined.
Abstract: Two mononuclear ruthenium(III) mer- and fac-isomers of the formula [RuCl3(PPh3)(dmpbt)] (where PPh3 = triphenylphosphine, dmpbt = 2-(3,5-dimethylpyrazoll-yl)benzothiazole) have been synthesised from the reaction of [RuCl3(PPh3)3] with a bidentate ligand – dmpbt. Appropriate reaction conditions allowed obtaining the two isomers separately without separation techniques. X-ray crystallography has determined the crystal and molecular structures of the new complexes. mer-Ru(III) (1) crystallised in the monoclinic P2(1)/n group, and fac-Ru(III) (2, 2′) in the triclinic P space group. The composition of the ruthenium coordination sphere was confirmed and characterised using spectroscopic techniques (FT-IR, UV-vis and EPR), elemental analysis and mass spectrometry (MS-FAB). The structures of the complexes obtained were analysed using X-ray and other spectroscopic methods (IR and UV-vis). The electrochemical properties of the ligand and the complex compound were identified using cyclic voltammetry, determining the potential and charge of faradaic processes. Both isomers are redox active and display quasi-reversible metal centered redox processes for the Ru(III)/Ru(II) pair. Moreover, preliminary tests of their biological activity were performed. The cytotoxicity of these compounds has been tested for human lung carcinoma (A549), chronic myelogenous leukemia (K562), human cervix carcinoma (HeLa) cells, acute lymphoblastic leukemia (MOLT-4), human breast adenocarcinoma cell line (MCF-7) and normal human umbilical vein endothelial cells (HUVEC). The ability to induce apoptosis has been demonstrated in caspase 3/7 activity assay. In addition, the lipophilicity of both isomers was described by a partition coefficient, log P, values of which were estimated by the shake-flask method. The interesting and promising preliminary results of the biological and chemical activities of the new octahedral mer/fac Ru(III) complexes motivate further in vitro and in vivo studies.

10 citations

Journal ArticleDOI
TL;DR: The oxomolybdenum(V) complexes are found to exhibit higher anticancer potency towards the cancer cells than the free ligand and structure activity relationship (SAR) studies indicate that the anticancer activity is to some extent dependent on the electronic effects of the halogen atom coordinated to the molyBdenum centre.

5 citations

Journal ArticleDOI
TL;DR: In this article, two new isostructural mononuclear dioxomolybdenum(VI) complexes of the formula MoO2X2L have been synthesized with a N N N donor 2-(3-methyl-5-phenyl pyrazol-1-yl) benzthiazole ligand (L).

5 citations