T
Tapsi Kumar
Researcher at University of Texas MD Anderson Cancer Center
Publications - 7
Citations - 624
Tapsi Kumar is an academic researcher from University of Texas MD Anderson Cancer Center. The author has contributed to research in topics: Cancer & Breast cancer. The author has an hindex of 4, co-authored 6 publications receiving 332 citations.
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Journal ArticleDOI
High prevalence of mutant KRAS in circulating exosome-derived DNA from early-stage pancreatic cancer patients.
Kelvin Allenson,J. Castillo,F.A. San Lucas,Ghislaine Scelo,D. U. Kim,Vincent Bernard,Greg Davis,Tapsi Kumar,Matthew H G Katz,Michael J. Overman,Lenka Foretová,E. Fabianova,Ivana Holcatova,Vladimir Janout,Vladimir Janout,Funda Meric-Bernstam,Peter R. C. Gascoyne,I. I. Wistuba,Gauri R. Varadhachary,Paul Brennan,Samir M. Hanash,Donghui Li,Anirban Maitra,Héctor M. Alvarez +23 more
TL;DR: Exosomes are a distinct source of tumor DNA that may be complementary to other liquid biopsy DNA sources that may limit its utility as a broad cancer-screening method.
Journal ArticleDOI
Delineating copy number and clonal substructure in human tumors from single-cell transcriptomes.
Ruli Gao,Ruli Gao,Shanshan Bai,Ying C. Henderson,Yiyun Lin,Aislyn Schalck,Yun Yan,Tapsi Kumar,Min Hu,Emi Sei,Alexander Davis,Fang Wang,Simona F. Shaitelman,Jennifer Wang,Ken Chen,Stacy L. Moulder,Stephen Y. Lai,Nicholas Navin +17 more
TL;DR: CopyKAT as discussed by the authors uses an integrative Bayesian segmentation approach called copy number karyotyping of aneuploid tumors to estimate genomic copy number profiles at an average genomic resolution of 5'mb from read depth in high-throughput single-cell RNA sequencing (scRNA-seq) data.
Journal ArticleDOI
Pre-existing Functional Heterogeneity of Tumorigenic Compartment as the Origin of Chemoresistance in Pancreatic Tumors
Sahil Seth,Chieh-Yuan Li,I-Lin Ho,Denise Corti,Sara Loponte,Luigi Sapio,Edoardo Del Poggetto,Er-Yen Yen,Frederick S. Robinson,Michael Peoples,Tatiana Karpinets,Angela K. Deem,Tapsi Kumar,Xingzhi Song,Shan Jiang,Ya'an Kang,Jason B. Fleming,Michael P. Kim,Jianhua Zhang,Anirban Maitra,Timothy P. Heffernan,Virginia Giuliani,Giannicola Genovese,Andrew Futreal,Giulio Draetta,Alessandro Carugo,Andrea Viale +26 more
TL;DR: Molecular annotation of gemcitabine-naive clonal lineages with distinct responses to treatment in the context of CRTs generated signatures that can predict the response to chemotherapy, representing a potential biomarker to stratify patients with pancreatic cancer.
Journal ArticleDOI
SCMarker: Ab initio marker selection for single cell transcriptome profiling.
TL;DR: This work presents an ab initio method that performs unsupervised marker selection by identifying genes that have subpopulation-discriminative expression levels and are co- or mutually-exclusively expressed with other genes.
Posted ContentDOI
Genomic profiling defines variable clonal relatedness between invasive breast cancer and primary ductal carcinoma in situ
Esther H. Lips,Tapsi Kumar,Anargyros Megalios,Lindy L. Visser,Michael Sheinman,Angelo Fortunato,Vandna Shah,Marlous Hoogstraat,Emi Sei,Diego Mallo,Maria Roman-Escorza,Ahmed A. Ahmed,Mingchu Xu,Wim Brugman,Karen Clements,Helen Davies,Liping Fu,Anita Grigoriadis,Timothy Hardman,Lorraine M. King,Marielle Krete,Petra Kristel,Michiel de Maaker,Carlo C. Maley,Jeffrey R. Marks,Brian A. Menegaz,Lennart Mulder,Frank Nieboer,Salpie Nowinski,Sarah E Pinder,Jelmar Quist,Carolina Salinas-Souza,Michael Schaapveld,Marjanka K. Schmidt,Abeer M Shaaban,Rana Shami,Mathini Sridharan,John Zhang,Hilary Stobart,Deborah Collyar,Serena Nik-Zainal,Lodewyk F. A. Wessels,Lodewyk F. A. Wessels,E. Shelley Hwang,Nicholas N. Navin,Andrew Futreal,Alastair M. Thompson,Jelle Wesseling,Jelle Wesseling,Elinor J. Sawyer +49 more
TL;DR: In this paper, the authors assessed the clonal relatedness of 143 cases of pure DCIS and their subsequent events using a combination of whole exome, targeted and copy number sequencing, supplemented by single cell analysis.