T
Tara Kenny
Researcher at United States Department of the Army
Publications - 34
Citations - 2312
Tara Kenny is an academic researcher from United States Department of the Army. The author has contributed to research in topics: Ebola virus & Virus. The author has an hindex of 17, co-authored 34 publications receiving 1878 citations. Previous affiliations of Tara Kenny include National Institutes of Health & United States Army Medical Research Institute of Infectious Diseases.
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Therapeutic efficacy of the small molecule GS-5734 against Ebola virus in rhesus monkeys
Travis K. Warren,Robert Jordan,Michael K. Lo,Adrian S. Ray,Richard L. Mackman,Veronica Soloveva,Dustin Siegel,Michel Perron,Roy Bannister,Hui Hon Chung,Nate Larson,Robert G. Strickley,Jay Wells,Kelly S. Stuthman,Sean A. Van Tongeren,Nicole L. Garza,Ginger Donnelly,Amy C. Shurtleff,Cary Retterer,Dima N. Gharaibeh,Rouzbeh Zamani,Tara Kenny,Brett P. Eaton,Elizabeth C. Grimes,Lisa S. Welch,Laura Gomba,Catherine L. Wilhelmsen,Donald K. Nichols,Jonathan E. Nuss,Elyse R. Nagle,Jeffrey R. Kugelman,Gustavo Palacios,Edward Doerffler,Sean Neville,Ernest Carra,Michael O. Clarke,Lijun Zhang,Willard Lew,Bruce Ross,Queenie Wang,Kwon Soo Chun,Lydia Wolfe,Darius Babusis,Yeojin Park,Kirsten M. Stray,Iva Trancheva,Joy Y. Feng,Ona Barauskas,Yili Xu,Pamela Wong,Molly R. Braun,Mike Flint,Laura K. McMullan,Shan Shan Chen,Rachel Fearns,S. Swaminathan,Douglas L. Mayers,Christina F. Spiropoulou,William A. Lee,Stuart T. Nichol,Tomas Cihlar,Sina Bavari +61 more
TL;DR: These results show the first substantive post-exposure protection by a small-molecule antiviral compound against EBOV in nonhuman primates, and the broad-spectrum antiviral activity of GS-5734 in vitro against other pathogenic RNA viruses, including filoviruses, arenavirus, and coronavirus suggests the potential for wider medical use.
Journal ArticleDOI
In vivo oligomerization and raft localization of Ebola virus protein VP40 during vesicular budding
Rekha G. Panchal,Gordon Ruthel,Tara Kenny,George Kallstrom,Douglas Lane,Shirin S. Badie,Limin Li,Sina Bavari,M. Javad Aman +8 more
TL;DR: By mutagenesis, this work identifies several critical C-terminal sequences that regulate oligomerization at the plasma membrane, association with detergent-resistant membranes, and vesicular release of VP40, directly linking these phenomena.
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A Multicomponent Animal Virus Isolated from Mosquitoes
Jason T. Ladner,Michael R. Wiley,Brett Beitzel,Albert J. Auguste,Alan P. Dupuis,Michael E. Lindquist,Samuel D. Sibley,Krishna P. Kota,David P Fetterer,Gillian Eastwood,David Kimmel,Karla Prieto,Hilda Guzman,Matthew T. Aliota,Daniel Reyes,Ernst E. Brueggemann,Lena St. John,David Hyeroba,Michael Lauck,Thomas C. Friedrich,David H. O’Connor,Marie C. Gestole,Lisa H. Cazares,Vsevolod L. Popov,Fanny Castro-Llanos,Tadeusz J. Kochel,Tara Kenny,Bailey White,Michael D. Ward,Jose R. Loaiza,Tony L. Goldberg,Tony L. Goldberg,Scott C. Weaver,Laura D. Kramer,Laura D. Kramer,Robert B. Tesh,Gustavo Palacios +36 more
TL;DR: This study characterize a multicomponent RNA virus isolated from mosquitoes, designated Guaico Culex virus (GCXV), which belongs to a diverse clade of segmented viruses (Jingmenvirus) related to the prototypically unsegmented Flaviviridae.
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Inhibition of metalloprotease botulinum serotype A from a pseudo-peptide binding mode to a small molecule that is active in primary neurons.
James C. Burnett,Gordon Ruthel,Christian Stegmann,Rekha G. Panchal,Tam Luong Nguyen,Ann R. Hermone,Robert G. Stafford,Douglas Lane,Tara Kenny,Connor F. McGrath,Peter Wipf,Andrea M. Stahl,James J. Schmidt,Rick Gussio,Axel T. Brunger,Sina Bavari +15 more
TL;DR: Of these, NSC 240898 is a promising lead for therapeutic development, as it readily enters neurons, exhibits no neuronal toxicity, and elicits dose-dependent protection of synaptosomal-associated protein in a primary culture of embryonic chicken neurons.
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Neuropathogenesis of Zika Virus in a Highly Susceptible Immunocompetent Mouse Model after Antibody Blockade of Type I Interferon.
Darci R. Smith,Bradley S. Hollidge,Sharon P. Daye,Xiankun Zeng,Candace D. Blancett,Kyle Kuszpit,Thomas M. Bocan,Jeffrey W. Koehler,Susan R. Coyne,T. D. Minogue,Tara Kenny,Xiaoli Chi,Soojin Yim,Lynn J. Miller,Connie S. Schmaljohn,Sina Bavari,Joseph W. Golden +16 more
TL;DR: This model of ZIKV pathogenesis will be valuable for evaluating medical countermeasures and the pathogenic mechanisms of ZikV because it allows immune responses to be elicited in immunologically competent mice with IFN I blockade only induced at the time of infection.