T
Tatiana D. Smirnova
Researcher at Russian Academy
Publications - 5
Citations - 160
Tatiana D. Smirnova is an academic researcher from Russian Academy. The author has contributed to research in topics: DNA damage & Apoptosis. The author has an hindex of 4, co-authored 5 publications receiving 141 citations.
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Journal ArticleDOI
Role of extracellular DNA oxidative modification in radiation induced bystander effects in human endotheliocytes
Svetlana V. Kostyuk,Aleksei V. Ermakov,Anna Yu. Alekseeva,Tatiana D. Smirnova,K. V. Glebova,Liudmila V. Efremova,Ancha Baranova,Ancha Baranova,Natalya N. Veiko +8 more
TL;DR: It is concluded that irradiation-related oxidation of the EcDNA is an important component of the ecDNA-mediated bystander effect.
Journal ArticleDOI
An extracellular DNA mediated bystander effect produced from low dose irradiated endothelial cells.
Aleksei V. Ermakov,Marina S. Konkova,Svetlana V. Kostyuk,Tatiana D. Smirnova,Elena M. Malinovskaya,Liudmila V. Efremova,Natalya N. Veiko +6 more
TL;DR: The presence of the radiation-induced apoptosis in the bystander effect being studied suggests a possibility for radiation-modified ecDNA fragments to be released into the culture medium, whereas inhibition of TLR9 suggests the binding these ligands to the recipient cells.
Journal ArticleDOI
An exposure to the oxidized DNA enhances both instability of genome and survival in cancer cells.
Svetlana V. Kostyuk,Marina S. Konkova,Elizaveta S. Ershova,Anna J. Alekseeva,Tatiana D. Smirnova,Sergey V. Stukalov,Ekaterina A. Kozhina,N. V. Shilova,Tatiana V. Zolotukhina,Zhanna G. Markova,V. L. Izhevskaya,Ancha Baranova,Ancha Baranova,Natalia N. Veiko +13 more
TL;DR: It is shown that oxidized extracellular DNA stimulates the survival of MCF-7 tumor cells, and survival of cells with an unstable genome may substantially augment progression of malignancy.
Journal ArticleDOI
GC-Rich Extracellular DNA Induces Oxidative Stress, Double-Strand DNA Breaks, and DNA Damage Response in Human Adipose-Derived Mesenchymal Stem Cells.
Svetlana V. Kostyuk,Tatiana D. Smirnova,Larisa V. Kameneva,Lev N. Porokhovnik,Anatolij Speranskij,Elizaveta S. Ershova,Sergey V. Stukalov,Vera Izevskaya,Natalia N. Veiko +8 more
TL;DR: It is shown that GC-rich extracellular DNA stimulates adipocyte differentiation of human adipose-derived mesenchymal stem cells (haMSCs) and may be one of the causes of obesity or osteoporosis.
Book ChapterDOI
GC-Rich DNA Fragments and Oxidized Cell-Free DNA Have Different Effects on NF-kB and NRF2 Signaling in MSC.
Vasilina A. Sergeeva,S. V. Kostyuk,Elizaveta S. Ershova,Elena M. Malinovskaya,Tatiana D. Smirnova,Larisa V. Kameneva,Natalia N. Veiko +6 more
TL;DR: This work investigated the time-dependent effect of oxidized and GC-rich cell-free DNA on NF-kB and NRF2 signaling pathways in human mesenchymal stem cells and showed that they affect cells in different ways.