T
Tatsuo Kawai
Researcher at Harvard University
Publications - 271
Citations - 12138
Tatsuo Kawai is an academic researcher from Harvard University. The author has contributed to research in topics: Transplantation & Kidney transplantation. The author has an hindex of 49, co-authored 254 publications receiving 10467 citations. Previous affiliations of Tatsuo Kawai include Aristotle University of Thessaloniki & University of California, San Francisco.
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Journal ArticleDOI
HLA-Mismatched Renal Transplantation without Maintenance Immunosuppression
Tatsuo Kawai,A. Benedict Cosimi,Thomas R. Spitzer,Nina Tolkoff-Rubin,Manikkam Suthanthiran,Susan L. Saidman,Juanita Shaffer,Frederic I. Preffer,Ruchuang Ding,Vijay K. Sharma,Jay A. Fishman,Bimalangshu R. Dey,Dicken S.C. Ko,Martin Hertl,Nelson Goes,Waichi Wong,Winfred W. Williams,Robert B. Colvin,Megan Sykes,David H. Sachs +19 more
TL;DR: Five patients with end-stage renal disease received combined bone marrow and kidney transplants from HLA single-haplotype mismatched living related donors, with the use of a nonmyeloablative preparative regimen, and it was possible to discontinue all immunosuppressive therapy 9 to 14 months after the transplantation.
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Strategies to improve long-term outcomes after renal transplantation.
TL;DR: Current antirejection therapy, including calcineurin blockers such as cyclosporine and tacrolimus, the interleukin-2 signal-transduction inhibitor sirolimus and the purine-synthesis inhibitor mycophenolate mofetil are discussed, which inhibits the proliferation of T cells and B cells.
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Angiotensin II Signal Transduction: An Update on Mechanisms of Physiology and Pathophysiology.
Steven J. Forrester,George W. Booz,Curt D. Sigmund,Thomas M. Coffman,Tatsuo Kawai,Victor Rizzo,Rosario Scalia,Satoru Eguchi +7 more
TL;DR: It is expected that rigorous translational research of the ANG II signaling pathways including those in large animals and humans will contribute to establishing effective new therapies against various diseases.
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Thromboembolic complications after treatment with monoclonal antibody against CD40 ligand.
TL;DR: In this article, the authors report that they developed thromboembolic complications after treatment with monoclonal antibody against CD40 ligand and showed that the antibody was ineffective.
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Mixed allogeneic chimerism and renal allograft tolerance in cynomolgus monkeys.
Tatsuo Kawai,Cosimi Ab,Robert B. Colvin,John A. Powelson,James D. Eason,Tomasz Kozlowski,Megan Sykes,Rodney L. Monroy,M Tanaka,David H. Sachs +9 more
TL;DR: At least transient engraftment of DBM appears to be essential for induction of donor specific tolerance in this monkey model of MHC-disparate nonhuman primates.