T
Ted Yednock
Researcher at Élan
Publications - 84
Citations - 12012
Ted Yednock is an academic researcher from Élan. The author has contributed to research in topics: Integrin & Epitope. The author has an hindex of 35, co-authored 78 publications receiving 11611 citations. Previous affiliations of Ted Yednock include University of California, San Francisco.
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Journal ArticleDOI
Immunization with amyloid-beta attenuates Alzheimer-disease-like pathology in the PDAPP mouse.
Dale Schenk,Robin Barbour,Whitney Dunn,Grace Gordon,Henry Grajeda,Teresa Guido,Kang Hu,Jiping Huang,Kelly Johnson-Wood,Karen Khan,Dora Kholodenko,Michael K. Lee,Zhenmei Liao,Ivan Lieberburg,Ruth Motter,Linda Mutter,Ferdie Soriano,George Shopp,Vasquez Nicki J,Christopher Vandevert,Shannan Walker,Mark Wogulis,Ted Yednock,Dora Games,Peter Seubert +24 more
TL;DR: It is reported that immunization of the young animals essentially prevented the development of β-amyloid-plaque formation, neuritic dystrophy and astrogliosis, and treatment of the older animals markedly reduced the extent and progression of these AD-like neuropathologies.
Journal ArticleDOI
Peripherally administered antibodies against amyloid beta-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease.
Frederique Bard,Catherine Cannon,Robin Barbour,Rae Lyn Burke,Dora Games,Henry Grajeda,Teresa Guido,Kang Hu,Jiping Huang,Kelly Johnson-Wood,Karen Khan,Dora Kholodenko,Michael K. Lee,Ivan Lieberburg,Ruth Motter,Minh Nguyen,Ferdie Soriano,Vasquez Nicki J,Kim Weiss,Brent Welch,Peter Seubert,Dale Schenk,Ted Yednock +22 more
TL;DR: Results indicate that antibodies can cross the blood–brain barrier to act directly in the central nervous system and should be considered as a therapeutic approach for the treatment of Alzheimer disease and other neurological disorders.
Journal ArticleDOI
Prevention of experimental autoimmune encephalomyelitis by antibodies against alpha 4 beta 1 integrin.
Ted Yednock,Catherine Cannon,Lawrence C. Fritz,Francisco Sánchez-Madrid,Lawrence Steinman,Nathan Karin +5 more
TL;DR: In vitro adhesion assay on tissue sections found that lymphocytes and monocytes bound selectively to inflamed EAE brain vessels, and therapies designed to interfere with α4βl integrin may be useful in treating inflammatory diseases of the central nervous system, such as multiple sclerosis.
Journal ArticleDOI
Cloning of a lymphocyte homing receptor reveals a lectin domain
Laurence A. Lasky,Mark S. Singer,Ted Yednock,Donald Dowbenko,Christopher Fennie,Henry Rodriguez,Thu Nguyen,Scott E. Stachel,Steven D. Rosen +8 more
TL;DR: Cl cloning of a murine cDNA that encodes the antigen recognized by the MEL-14 antibody shows that it contains a lectin domain that appears to be involved in the binding of lymphocytes to peripheral lymph node endothelium, thus defining a new type of cellular adhesion molecule.
Journal ArticleDOI
Epitope and isotype specificities of antibodies to β-amyloid peptide for protection against Alzheimer's disease-like neuropathology
Frederique Bard,Robin Barbour,Catherine Cannon,Robert Carretto,Michael Fox,Dora Games,Teresa Guido,Kathleen Hoenow,Kang Hu,Kelly Johnson-Wood,Karen Khan,Dora Kholodenko,Celeste Lee,Michael K. Lee,Ruth Motter,Minh Nguyen,Amanda Reed,Dale Schenk,Pearl Tang,Vasquez Nicki J,P. Seubert,Ted Yednock +21 more
TL;DR: Results indicate that antibody Fc-mediated plaque clearance is a highly efficient and effective process for protection against neuropathology in an animal model of Alzheimer's disease.