T
Teresa L. Burgess
Researcher at Amgen
Publications - 43
Citations - 7567
Teresa L. Burgess is an academic researcher from Amgen. The author has contributed to research in topics: Hepatocyte growth factor & Receptor tyrosine kinase. The author has an hindex of 23, co-authored 42 publications receiving 7275 citations. Previous affiliations of Teresa L. Burgess include University of California, Santa Barbara & National Institutes of Health.
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Journal ArticleDOI
Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE.
Robert Vassar,Brian D. Bennett,Safura Babu-Khan,Steve Kahn,Elizabeth A. Mendiaz,Paul Denis,David B. Teplow,Sandra Ross,Patricia Amarante,Richard Loeloff,Yi Luo,Seth Fisher,Janis Fuller,Steven P. Edenson,Jackson Lile,Mark A. Jarosinski,Anja Leona Biere,Eileen Curran,Teresa L. Burgess,Jean Claude Louis,Frank H. Collins,James J. S. Treanor,Gary Rogers,Martin Citron +23 more
TL;DR: Overexpression of a transmembrane aspartic protease, termed BACE (for beta-site APP-cleaving enzyme) increased the amount of beta-secretase cleavage products, and these were cleaved exactly and only at known beta- secretase positions.
Journal ArticleDOI
The Ligand for Osteoprotegerin (OPGL) Directly Activates Mature Osteoclasts
Teresa L. Burgess,Yi-xin Qian,Stephen Kaufman,Brian D. Ring,Gwyneth Van,C. Capparelli,Michael J. Kelley,Hailing Hsu,William J. Boyle,Colin R. Dunstan,Sylvia Hu,David L. Lacey +11 more
TL;DR: Findings indicate that, in addition to their effects on OC precursors, OPGL and OPG have profound and direct effects on mature OCs and indicate that the OC receptor, RANK, mediates OPGl's effects.
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Osteoprotegerin Ligand Modulates Murine Osteoclast Survival in Vitro and in Vivo
David L. Lacey,Hong Lin Tan,John Lu,Steven Kaufman,Gwyneth Van,Wanrang Qiu,Alana Rattan,Sheila Scully,Frederick A. Fletcher,Todd Juan,Michael J. Kelley,Teresa L. Burgess,William J. Boyle,Anthony Polverino +13 more
TL;DR: In mice, a single dose of OPG, the OPGL decoy receptor, led to a >90% loss of osteoclasts because of apoptosis within 48 hours of exposure without impacting osteoclast precursor cells and endogenous CSF-1 levels are insufficient to maintain osteoc last viability in the absence of O PGL.
Journal ArticleDOI
The antiproliferative activity of c-myb and c-myc antisense oligonucleotides in smooth muscle cells is caused by a nonantisense mechanism.
Teresa L. Burgess,E F Fisher,S L Ross,J V Bready,Yi-xin Qian,L A Bayewitch,A M Cohen,C J Herrera,Sylvia Hu,T B Kramer +9 more
TL;DR: The results suggest that previous AS data obtained using these and similar, contiguous guanosine-containing AS sequences be reevaluated and that there may be an additional class of nucleic acid compounds that have potential as antirestenosis therapeutics.
Journal ArticleDOI
Fully Human Monoclonal Antibodies to Hepatocyte Growth Factor with Therapeutic Potential against Hepatocyte Growth Factor/c-Met–Dependent Human Tumors
Teresa L. Burgess,Angela Coxon,Susanne Meyer,Jan Sun,Karen Rex,Trace Tsuruda,Qing Chen,Shu-Yin Ho,Luke Li,Stephen J. Kaufman,Kevin McDorman,Russell C. Cattley,Jilin Sun,Gary Elliott,Ke Zhang,Xiao Feng,Xiao-Chi Jia,Larry L. Green,Robert Radinsky,Richard Kendall +19 more
TL;DR: Results suggest that an antibody to an epitope in the beta-chain of HGF has potential as a novel therapeutic agent for treating patients with HGF-dependent tumor growth and caused significant regression of established U-87 MG tumor xenografts.