Tetsu Tanaka

Bio: Tetsu Tanaka is an academic researcher from Tohoku University. The author has contributed to research in topics: Wafer & Chip. The author has an hindex of 38, co-authored 406 publications receiving 10375 citations. Previous affiliations of Tetsu Tanaka include NTT DoCoMo & Tokyo Medical and Dental University.

Magnetocrystalline Anisotropy and Magnetostriction for Fe-(4 to 6 wt%) Si-(2 to 5 wt%) Al Alloy Single Crystals

Abstract: The temperature dependences of the magnetocrystalline anisotropy constant K 1 and the magnetostriction constants ? 100 and ? 111 were measured for Fe-Si-Al alloy single crystals in the composition range 4 to 6 wt% Si, 2 to 5 wt% Al, balance Fe, after being slowly cooled from 1200°C or quenching from 1200°C. The crystal structure of these single crystal samples was determined by electron diffraction. The large difference in the magnitudes of K 1 =9.1×103 erg/cm3 for 4.8 wt% Si, 5.0 wt% Al, bal. Fe alloy, and K 1 =9.1×105 erg/cm3 for 4.7 wt% Si, 3.8 wt% Al, bal. Fe alloy was found to be connected with the difference in their crystal structures. The ? 100 =0 and ? 111 =0 equal-value line were identified on a composition diagram. The concentration of the alloy at which the second peak in ?m occurs is located along the ? 100 = 0 line Moreover, this second peak alloy may have the Do 3 structure.

Development of Si Opto-Neural Probe with Multiple Optical Waveguides and Metal-cover as Versatile Tool for Optogenetics

Abstract: 1 Department of Biomedical Engineering, Graduate School of Biomedical Engineering, Tohoku University 6-6-01 Aza-Aoba, Aramaki, Aoba-ku, Sendai 980-8579, Japan Phone: +81-22-795-6258, Fax: +81-22-795-6908, E-mail: link@lbc.mech.tohoku.ac.jp 2 Department of Biology and Neuroscience, Graduate School of Life Sciences, Tohoku University 3 Department of Applied Information Science, Tohoku University 4 Department of Physiology, Tohoku University School of Medicine

Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence

Abstract: Countless millions of people have died from tuberculosis, a chronic infectious disease caused by the tubercle bacillus. The complete genome sequence of the best-characterized strain of Mycobacterium tuberculosis, H37Rv, has been determined and analysed in order to improve our understanding of the biology of this slow-growing pathogen and to help the conception of new prophylactic and therapeutic interventions. The genome comprises 4,411,529 base pairs, contains around 4,000 genes, and has a very high guanine + cytosine content that is reflected in the biased amino-acid content of the proteins. M. tuberculosis differs radically from other bacteria in that a very large portion of its coding capacity is devoted to the production of enzymes involved in lipogenesis and lipolysis, and to two new families of glycine-rich proteins with a repetitive structure that may represent a source of antigenic variation.

Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease

Abstract: BackgroundExperimental and clinical data suggest that reducing inflammation without affecting lipid levels may reduce the risk of cardiovascular disease. Yet, the inflammatory hypothesis of atherothrombosis has remained unproved. MethodsWe conducted a randomized, double-blind trial of canakinumab, a therapeutic monoclonal antibody targeting interleukin-1β, involving 10,061 patients with previous myocardial infarction and a high-sensitivity C-reactive protein level of 2 mg or more per liter. The trial compared three doses of canakinumab (50 mg, 150 mg, and 300 mg, administered subcutaneously every 3 months) with placebo. The primary efficacy end point was nonfatal myocardial infarction, nonfatal stroke, or cardiovascular death. ResultsAt 48 months, the median reduction from baseline in the high-sensitivity C-reactive protein level was 26 percentage points greater in the group that received the 50-mg dose of canakinumab, 37 percentage points greater in the 150-mg group, and 41 percentage points greater in t...

Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic pathogen.

Abstract: Pseudomonas aeruginosa is a ubiquitous environmental bacterium that is one of the top three causes of opportunistic human infections. A major factor in its prominence as a pathogen is its intrinsic resistance to antibiotics and disinfectants. Here we report the complete sequence of P. aeruginosa strain PAO1. At 6.3 million base pairs, this is the largest bacterial genome sequenced, and the sequence provides insights into the basis of the versatility and intrinsic drug resistance of P. aeruginosa. Consistent with its larger genome size and environmental adaptability, P. aeruginosa contains the highest proportion of regulatory genes observed for a bacterial genome and a large number of genes involved in the catabolism, transport and efflux of organic compounds as well as four potential chemotaxis systems. We propose that the size and complexity of the P. aeruginosa genome reflect an evolutionary adaptation permitting it to thrive in diverse environments and resist the effects of a variety of antimicrobial substances.