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Author

Tetsu Tanaka

Other affiliations: NTT DoCoMo, Tokyo Medical and Dental University, Fujitsu  ...read more
Bio: Tetsu Tanaka is an academic researcher from Tohoku University. The author has contributed to research in topics: Wafer & Chip. The author has an hindex of 38, co-authored 406 publications receiving 10375 citations. Previous affiliations of Tetsu Tanaka include NTT DoCoMo & Tokyo Medical and Dental University.
Topics: Wafer, Chip, Wafer bonding, Interposer, Flip chip


Papers
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Proceedings ArticleDOI
01 Oct 2017
TL;DR: The proposed GIDL-controlled oscillator circuit successfully oscillated at ultralow frequency of 3.1Hz, and the impedance measurement circuit completely outputs square waveforms with a current amplitude of 50pA, which can measure impedance ranges from 100Ω to 100MΩ.
Abstract: This paper presents area efficient and ultrawide range square wave impedance analysis circuit for biomedical applications. By using a gate-induced drain-leakage current (GIDL), we designed an ultralow current generation circuit which is a key component of the impedance measurement circuit and a GIDL-controlled oscillator operating at ultralow frequency. In addition, the area of the impedance measurement circuit becomes remarkably small due to square waveform current. All impedance measurement circuits are fabricated with a 0.18μm 1P6M standard CMOS technology and occupy 0.43mm2. As results, the proposed GIDL-controlled oscillator circuit successfully oscillated at ultralow frequency of 3.1Hz, and the impedance measurement circuit completely outputs square waveforms with a current amplitude of 50pA. The proposed circuit can measure impedance ranges from 100Ω to 100MΩ.

1 citations

Journal ArticleDOI
TL;DR: In this paper, a new method of evaluating the magnetization reversal mechanism is used for both single and double-layer Co-Cr films, where the mechanism for thick films is by rotation and for thin films it is by domain wall motion.
Abstract: A new method of evaluating the magnetization reversal mechanism is used for both single- and double-layer Co-Cr films. The mechanism for thick films is by rotation and for thin films it is by domain wall motion. The mechanism for any given film is evaluated by angular dependence of the hysteresis loss and coercive force for the films of thickness above 380 A, the magnetization reversal mechanism takes place by rotation. At 250 A, the film shows the tendencies of the magnetization reversal by domain wall motion. The investigation has suggested the pseudo double-layer structure with respect to the magnetization mechanism in single-layer films.

1 citations

Book ChapterDOI
TL;DR: An ultrathin fluorescence endoscope imaging system that can image cells in the brain at any depth while minimizing the invasion and perform imaging and optical stimulation simultaneously is developed and successfully visualized neurons expressing GFP with single-cell resolution.
Abstract: To elucidate the expression mechanisms of brain functions, we have developed an ultrathin fluorescence endoscope imaging system (U-FEIS) that can image cells in the brain at any depth while minimizing the invasion. The endoscope part of U-FEIS consists of a GRIN lens and a 10,000-pixel image fiber with a diameter of 450 μm. The specialized microscope of U-FEIS is within 30 cm square and includes lenses and optical filters optimized for the endoscope. Using U-FEIS, we successfully visualized neurons expressing GFP with single-cell resolution and recorded the multineuronal activities in vitro and in vivo. U-FEIS can also perform imaging and optical stimulation simultaneously. Therefore, U-FEIS should be a powerful optical tool in neuroscience research.

1 citations


Cited by
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Journal ArticleDOI
11 Jun 1998-Nature
TL;DR: The complete genome sequence of the best-characterized strain of Mycobacterium tuberculosis, H37Rv, has been determined and analysed in order to improve the understanding of the biology of this slow-growing pathogen and to help the conception of new prophylactic and therapeutic interventions.
Abstract: Countless millions of people have died from tuberculosis, a chronic infectious disease caused by the tubercle bacillus. The complete genome sequence of the best-characterized strain of Mycobacterium tuberculosis, H37Rv, has been determined and analysed in order to improve our understanding of the biology of this slow-growing pathogen and to help the conception of new prophylactic and therapeutic interventions. The genome comprises 4,411,529 base pairs, contains around 4,000 genes, and has a very high guanine + cytosine content that is reflected in the biased amino-acid content of the proteins. M. tuberculosis differs radically from other bacteria in that a very large portion of its coding capacity is devoted to the production of enzymes involved in lipogenesis and lipolysis, and to two new families of glycine-rich proteins with a repetitive structure that may represent a source of antigenic variation.

7,779 citations

Journal ArticleDOI
TL;DR: Antiinflammatory therapy targeting the interleukin‐1β innate immunity pathway with canakinumab at a dose of 150 mg every 3 months led to a significantly lower rate of recurrent cardiovascular events than placebo, independent of lipid‐level lowering.
Abstract: BackgroundExperimental and clinical data suggest that reducing inflammation without affecting lipid levels may reduce the risk of cardiovascular disease. Yet, the inflammatory hypothesis of atherothrombosis has remained unproved. MethodsWe conducted a randomized, double-blind trial of canakinumab, a therapeutic monoclonal antibody targeting interleukin-1β, involving 10,061 patients with previous myocardial infarction and a high-sensitivity C-reactive protein level of 2 mg or more per liter. The trial compared three doses of canakinumab (50 mg, 150 mg, and 300 mg, administered subcutaneously every 3 months) with placebo. The primary efficacy end point was nonfatal myocardial infarction, nonfatal stroke, or cardiovascular death. ResultsAt 48 months, the median reduction from baseline in the high-sensitivity C-reactive protein level was 26 percentage points greater in the group that received the 50-mg dose of canakinumab, 37 percentage points greater in the 150-mg group, and 41 percentage points greater in t...

5,660 citations

Journal ArticleDOI
31 Aug 2000-Nature
TL;DR: It is proposed that the size and complexity of the P. aeruginosa genome reflect an evolutionary adaptation permitting it to thrive in diverse environments and resist the effects of a variety of antimicrobial substances.
Abstract: Pseudomonas aeruginosa is a ubiquitous environmental bacterium that is one of the top three causes of opportunistic human infections. A major factor in its prominence as a pathogen is its intrinsic resistance to antibiotics and disinfectants. Here we report the complete sequence of P. aeruginosa strain PAO1. At 6.3 million base pairs, this is the largest bacterial genome sequenced, and the sequence provides insights into the basis of the versatility and intrinsic drug resistance of P. aeruginosa. Consistent with its larger genome size and environmental adaptability, P. aeruginosa contains the highest proportion of regulatory genes observed for a bacterial genome and a large number of genes involved in the catabolism, transport and efflux of organic compounds as well as four potential chemotaxis systems. We propose that the size and complexity of the P. aeruginosa genome reflect an evolutionary adaptation permitting it to thrive in diverse environments and resist the effects of a variety of antimicrobial substances.

4,220 citations