Tetsu Tanaka

Bio: Tetsu Tanaka is an academic researcher from Tohoku University. The author has contributed to research in topics: Wafer & Chip. The author has an hindex of 38, co-authored 406 publications receiving 10375 citations. Previous affiliations of Tetsu Tanaka include NTT DoCoMo & Tokyo Medical and Dental University.

Advanced 2.5D/3D hetero-integration technologies at GINTI, Tohoku University

Abstract: The Global Integration Initiative (GINTI) is 8/12-inch R&D foundry fab for the research and development of new 2.5D/3D integration technologies and creative applications. GINTI offers a broad range of services to meet the mounting R&D needs of the semiconductor industry and related industries. GINTI provides a cost-competitive process development infrastructure in a manufacturing-like fab environment and a low-cost, short TAT prototyping of proof of concepts using commercial/customized 2D chip/wafer, and a base-line process set-up for the pilot production of creative 3D systems. GINTI aims to provide Tohoku University's advanced 2.5D/3D integration technologies into electronic industries to accelerate the commercialization of innovative 3D technologies and applications into real, manufacturing-ready technology solutions with FAST. This paper introduces advanced 2.5D/3D hetero-integration technologies developed by GINTI/Tohoku University.

Implementation of Light and Dark Adaptation Function for High QOL 3D-Stacked Artificial Retina Chip

Abstract: The increase in the number of visually impaired people has led to active research on artificial retinas. In our laboratory, we study a fully-implantable retinal prosthesis using a 3D-stacked artificial retina chip, which provides highly visible visual information with edge enhancement and binarization functions. However, since the visibility of objects can be significantly reduced when the ambient illumination is low, the light and dark adaptation (LDA) function is needed to provide the same visibility regardless of the ambient illumination. Conventional LDA functions have operability, comfort, and circuit area problems in these situations. In this study, we proposed a small-area LDA function circuit that provided visual information with high quality of life and evaluated a prototype circuit.

3D-stacked retinal prosthesis chip with binary image capture and edge detection functions for human visual restoration

Abstract: Retinal prosthesis is a promising treatment for vision degeneration. However, clinical experiments show that the patients can only recognize several grayscales at low resolution with electrical stimulation. This paper proposes a retinal prosthesis chip with binarization and edge detection functions to maximize the brightness difference and reduce redundant information. The binarization operation is designed as a column-parallel processing element for saving space. Moreover, the fill factor achieves 50.79% by separating the sensor and stimulator into different chips. Finally, the SPICE simulator verified the effectiveness of the proposed circuit, which achieves an FoM of 110nW/(frame·pixel).

Highly Reliable Dynamic Random Access Memory Technology for Application Specific Memory with Dual Nitrogen Concentration Gate Oxynitrides Using Selective Nitrogen Implantation

Abstract: A polymetal dual gate dynamic random access memory (DRAM) for application specific memory (ASM) with dual nitrogen concentrated oxynitrides was developed for the first time. This technology uses selective nitrogen implantation performed just after gate oxidation. The nitrogen concentration of p-type metal oxide semiconductor (PMOS) in gate dielectric combined with nitrogen implantation and NO (nitric oxide) annealing is sufficiently high to suppress boron penetration, whereas that of the cell array transistor (cell-Tr) and n-type metal oxide semiconductor (NMOS) is sufficiently low to maintain the threshold voltage (Vth) without increasing the channel dosage by using only NO annealing.

Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence

Abstract: Countless millions of people have died from tuberculosis, a chronic infectious disease caused by the tubercle bacillus. The complete genome sequence of the best-characterized strain of Mycobacterium tuberculosis, H37Rv, has been determined and analysed in order to improve our understanding of the biology of this slow-growing pathogen and to help the conception of new prophylactic and therapeutic interventions. The genome comprises 4,411,529 base pairs, contains around 4,000 genes, and has a very high guanine + cytosine content that is reflected in the biased amino-acid content of the proteins. M. tuberculosis differs radically from other bacteria in that a very large portion of its coding capacity is devoted to the production of enzymes involved in lipogenesis and lipolysis, and to two new families of glycine-rich proteins with a repetitive structure that may represent a source of antigenic variation.

Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease

Abstract: BackgroundExperimental and clinical data suggest that reducing inflammation without affecting lipid levels may reduce the risk of cardiovascular disease. Yet, the inflammatory hypothesis of atherothrombosis has remained unproved. MethodsWe conducted a randomized, double-blind trial of canakinumab, a therapeutic monoclonal antibody targeting interleukin-1β, involving 10,061 patients with previous myocardial infarction and a high-sensitivity C-reactive protein level of 2 mg or more per liter. The trial compared three doses of canakinumab (50 mg, 150 mg, and 300 mg, administered subcutaneously every 3 months) with placebo. The primary efficacy end point was nonfatal myocardial infarction, nonfatal stroke, or cardiovascular death. ResultsAt 48 months, the median reduction from baseline in the high-sensitivity C-reactive protein level was 26 percentage points greater in the group that received the 50-mg dose of canakinumab, 37 percentage points greater in the 150-mg group, and 41 percentage points greater in t...

Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic pathogen.

Abstract: Pseudomonas aeruginosa is a ubiquitous environmental bacterium that is one of the top three causes of opportunistic human infections. A major factor in its prominence as a pathogen is its intrinsic resistance to antibiotics and disinfectants. Here we report the complete sequence of P. aeruginosa strain PAO1. At 6.3 million base pairs, this is the largest bacterial genome sequenced, and the sequence provides insights into the basis of the versatility and intrinsic drug resistance of P. aeruginosa. Consistent with its larger genome size and environmental adaptability, P. aeruginosa contains the highest proportion of regulatory genes observed for a bacterial genome and a large number of genes involved in the catabolism, transport and efflux of organic compounds as well as four potential chemotaxis systems. We propose that the size and complexity of the P. aeruginosa genome reflect an evolutionary adaptation permitting it to thrive in diverse environments and resist the effects of a variety of antimicrobial substances.