T
Theodore L. Goodfriend
Researcher at University of Wisconsin-Madison
Publications - 92
Citations - 6946
Theodore L. Goodfriend is an academic researcher from University of Wisconsin-Madison. The author has contributed to research in topics: Aldosterone & Angiotensin II. The author has an hindex of 34, co-authored 91 publications receiving 6372 citations. Previous affiliations of Theodore L. Goodfriend include Medical College of Wisconsin & University of Colorado Boulder.
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Journal ArticleDOI
The Human Serum Metabolome
Nikolaos Psychogios,David Hau,Jun Peng,An Chi Guo,Rupasri Mandal,Souhaila Bouatra,Igor Sinelnikov,Ramanarayan Krishnamurthy,Roman Eisner,Bijaya Gautam,Nelson Young,Jianguo Xia,Craig Knox,Edison Dong,Paul Huang,Zsuzsanna Hollander,Theresa L. Pedersen,Steven R. Smith,Fiona Bamforth,Russell Greiner,Bruce M. McManus,John W. Newman,Theodore L. Goodfriend,David S. Wishart,David S. Wishart +24 more
TL;DR: This work has combined targeted and non-targeted NMR, GC-MS and LC-MS methods with computer-aided literature mining to identify and quantify a comprehensive, if not absolutely complete, set of metabolites commonly detected and quantified (with today's technology) in the human serum metabolome.
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Insulin resistance and cardiovascular disease
TL;DR: A clearer delineation of the key reactive oxygen signaling pathways and the impact of various interventions on these pathways could facilitate a rationale approach to antioxidant therapy and improved outcomes among the rapidly growing number of high-risk, insulin-resistant, obese individuals.
Journal ArticleDOI
Angiotensin Receptors and Their Antagonists
TL;DR: The intrarenal renin–angiotensin system affects glomerular filtration, as discussed below, but the importance of ang Elliotensin synthesis in other tissues is not known.
Journal Article
Effect of spironolactone on blood pressure in subjects with resistant hypertension. Commentary
Theodore L. Goodfriend,Neil Chapman,Joanna Dobson,Sarah Wilson,Björn Dahlöf,Peter S. Sever,Hans Wedel,Neil R Poulter +7 more
TL;DR: Evaluated among 1411 participants in the Anglo-Scandinavian Cardiac Outcomes Trial-Blood Pressure Lowering Arm, the use of spironolactone in uncontrolled hypertension effectively lowers blood pressure in patients with hypertension uncontrolled by a mean of ≈3 other drugs is supported.
Journal ArticleDOI
Resistant Hypertension, Obesity, Sleep Apnea, and Aldosterone: Theory and Therapy
TL;DR: It is suggested that refractoriness among obese hypertensives is frequently caused by obstructive sleep apnea and/or inappropriately high plasma aldosterone levels.