Thierry Fandeur

TL;DR: Strong correlations between the presence of a mutant allele, in vitro parasite survival rates and in vivo parasite clearance rates indicate that K13-propeller mutations are important determinants of artemisinin resistance.

TL;DR: A rise in resistance to artemisinin derivatives in field isolates indicates the need for increased vigilance and a coordinated and rapid deployment of drug combinations.

TL;DR: In this article, the authors analyzed the K13-propeller sequence polymorphism in 14,037 samples collected in 59 countries in which malaria is endemic and identified 108 nonsynonymous K13 mutations, which showed marked geographic disparity in their frequency and distribution.

TL;DR: Artemisinin combination therapies have recently been adopted as first-line therapy for Plasmodium falciparum infections in most malaria-endemic countries and should be evaluated further as a surveillance tool for artesunate-mefloquine resistance in Cambodia.

TL;DR: This study shows that pfmdr1 copy number is a molecular marker of AM treatment failure in falciparum malaria on the Thai-Cambodian border, however, while it is associated with increased IC50 for lumefantrine, pfmDr1copy number is not associated with AL treatment failure on the area, suggesting involvement of other molecular mechanisms in AL treatment failures in Cambodia.