T
Thierry Garnier
Researcher at Pasteur Institute
Publications - 54
Citations - 17608
Thierry Garnier is an academic researcher from Pasteur Institute. The author has contributed to research in topics: Gene & Clostridium perfringens. The author has an hindex of 36, co-authored 54 publications receiving 16900 citations. Previous affiliations of Thierry Garnier include Centre national de la recherche scientifique.
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Journal ArticleDOI
Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence
Stewart T. Cole,Roland Brosch,Julian Parkhill,Thierry Garnier,Carol Churcher,David Harris,Stephen V. Gordon,Karin Eiglmeier,S. Gas,Clifton E. Barry,Fredj Tekaia,K. Badcock,D. Basham,D. Brown,Tracey Chillingworth,R. Connor,Robert L. Davies,K. Devlin,Theresa Feltwell,S. Gentles,N. Hamlin,S. Holroyd,T. Hornsby,Kay Jagels,Anders Krogh,J. McLean,Sharon Moule,Lee Murphy,K. Oliver,J. Osborne,Michael A. Quail,Marie-Adèle Rajandream,Jane Rogers,S. Rutter,K. Seeger,Jason Skelton,Rob Squares,S. Squares,John Sulston,K. Taylor,Sally Whitehead,Bart Barrell +41 more
TL;DR: The complete genome sequence of the best-characterized strain of Mycobacterium tuberculosis, H37Rv, has been determined and analysed in order to improve the understanding of the biology of this slow-growing pathogen and to help the conception of new prophylactic and therapeutic interventions.
Journal ArticleDOI
Massive gene decay in the leprosy bacillus
Stewart T. Cole,Karin Eiglmeier,Julian Parkhill,Keith D. James,Nicholas R. Thomson,Paul R. Wheeler,Nadine Honoré,Thierry Garnier,Carol Churcher,David Harris,Karen Mungall,D. Basham,D. Brown,Tracey Chillingworth,R. Connor,Robert L. Davies,K. Devlin,Stephanie Duthoy,Theresa Feltwell,Audrey Fraser,N. Hamlin,S. Holroyd,T. Hornsby,Kay Jagels,Céline Lacroix,J. Maclean,Sharon Moule,Lee Murphy,K. Oliver,Michael A. Quail,Marie-Adèle Rajandream,Kim Rutherford,S. Rutter,K. Seeger,Sylvie Simon,Mark Simmonds,Jason Skelton,Rob Squares,S. Squares,K. Stevens,K. Taylor,Sally Whitehead,J. R. Woodward,Bart Barrell +43 more
TL;DR: Comparing the 3.27-megabase genome sequence of an armadillo-derived Indian isolate of the leprosy bacillus with that of Mycobacterium tuberculosis provides clear explanations for these properties and reveals an extreme case of reductive evolution.
Journal ArticleDOI
A new evolutionary scenario for the Mycobacterium tuberculosis complex
Roland Brosch,Stephen V. Gordon,M. Marmiesse,Priscille Brodin,Carmen Buchrieser,Karin Eiglmeier,Thierry Garnier,C. Gutierrez,Glyn Hewinson,Kristin Kremer,Linda M. Parsons,Alexander S. Pym,Sofía Samper,D. van Soolingen,Stewart T. Cole +14 more
TL;DR: The distribution of 20 variable regions resulting from insertion-deletion events in the genomes of the tubercle bacilli has been evaluated and contradict the often-presented hypothesis that M. tuberculosis, the etiological agent of human tuberculosis evolved from M. bovis, the agent of bovine disease.
Journal ArticleDOI
The complete genome sequence of Mycobacterium bovis
Thierry Garnier,Karin Eiglmeier,Jean-Christophe Camus,Nadine Medina,Huma Mansoor,Melinda J. Pryor,Stephanie Duthoy,Sophie Grondin,Céline Lacroix,Christel Monsempe,Sylvie Simon,Barbara Harris,Rebecca Atkin,Jon Doggett,Rebecca Mayes,Lisa Keating,Paul R. Wheeler,Julian Parkhill,Bart Barrell,Stewart T. Cole,Stephen V. Gordon,R. Glyn Hewinson +21 more
TL;DR: The genome sequence offers major insight on the evolution, host preference, and pathobiology of M. bovis, implying that differential gene expression may be the key to the host tropisms of human and bovine bacilli.
Journal ArticleDOI
Identification of variable regions in the genomes of tubercle bacilli using bacterial artificial chromosome arrays.
Stephen V. Gordon,Roland Brosch,Alain Billault,Thierry Garnier,Karin Eiglmeier,Stewart T. Cole +5 more
TL;DR: Comparisons of the BAC libraries of Mycobacterium tuberculosis and the vaccine strain and the complete genome sequence of M. bovis BCG uncovered a third class of deletions consisting of two M. tuberculosis H37Rv loci, RvD1 and RVD2, deleted from the genome relative to M.bovis.