T
Thimios A. Mitsiadis
Researcher at University of Zurich
Publications - 160
Citations - 7816
Thimios A. Mitsiadis is an academic researcher from University of Zurich. The author has contributed to research in topics: Stem cell & Notch signaling pathway. The author has an hindex of 49, co-authored 152 publications receiving 7007 citations. Previous affiliations of Thimios A. Mitsiadis include University of Helsinki & King's College London.
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Journal ArticleDOI
Mesenchymal multipotency of adult human periosteal cells demonstrated by single‐cell lineage analysis
Cosimo De Bari,Francesco Dell'Accio,Johan Vanlauwe,Jeroen Eyckmans,Ilyas M. Khan,Charles W. Archer,Elena Jones,Dennis McGonagle,Thimios A. Mitsiadis,Costantino Pitzalis,Frank P. Luyten +10 more
TL;DR: It is demonstrated that, regardless of donor age, the adult human periosteum contains cells that, upon enzymatic release and culture expansion, are multipotent MSCs at the single-cell level.
Journal ArticleDOI
Expression of the heparin-binding cytokines, midkine (MK) and HB-GAM (pleiotrophin) is associated with epithelial-mesenchymal interactions during fetal development and organogenesis
Thimios A. Mitsiadis,M. Salmivirta,Takashi Muramatsu,H. Muramatsu,Heikki Rauvala,Eero Lehtonen,Markku Jalkanen,Irma Thesleff +7 more
TL;DR: Results indicate that MK and HB-GAM may play regulatory roles in differentiation and morphogenesis of the vertebrate embryo, particularly in epithelio-mesenchymal organs, and suggest molecular interactions with syndecan-1.
Journal ArticleDOI
Human dentin production in vitro.
Imad About,Marie-José Bottero,Philippe de Denato,Jean Camps,Jean-Claude Franquin,Thimios A. Mitsiadis +5 more
TL;DR: The immunohistochemical study revealed that, as odontoblasts, pulp cells contributing to the nodule formation express type I collagen, osteonectin, and nestin, which show that both the molecular and the mineral characteristics of the human dentin matrix are respected in the in vitro culture conditions.
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Retinoid X receptor heterodimerization and developmental expression distinguish the orphan nuclear receptors NGFI-B, Nurr1, and Nor1.
TL;DR: It is demonstrated that the most recently identified member of the NGFI-B/Nurr1/Nor1 subfamily shows similar monomer DNA-binding and constitutive transactivation properties as NGFI -B and Nurr1, however, Nor1 is unable to promote RXR signaling due to its inability to form heterodimers with RXR.
Journal ArticleDOI
Stem cell niches in mammals
TL;DR: Recent progress made on the anatomical and molecular characterization of mammalian stem cell niches is highlighted, focusing particularly on bone marrow, tooth and hair follicle.