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Thomas Bayer
Researcher at University of Greifswald
Publications - 6
Citations - 228
Thomas Bayer is an academic researcher from University of Greifswald. The author has contributed to research in topics: Monooxygenase & Enantioselective synthesis. The author has an hindex of 4, co-authored 6 publications receiving 74 citations. Previous affiliations of Thomas Bayer include Vienna University of Technology.
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Recent trends in biocatalysis
Dong Yi,Thomas Bayer,Christoffel P. S. Badenhorst,Shuke Wu,Mark Doerr,Matthias Höhne,Uwe T. Bornscheuer +6 more
TL;DR: The research of biocatalysis is gradually moving towards the era of novel technology integration, intelligent manufacturing and enzymatic total synthesis, and gradually complements the lack of remaining key steps in the pathway design of enzyme total synthesis.
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Designer Microorganisms for Optimized Redox Cascade Reactions – Challenges and Future Perspectives
TL;DR: This review will focus on genetic and metabolic engineering tools for the assembly and introduction of de novo redox pathways into the host Escherichia coli and will present state of the art redox cascades performed by tailor-made microbial cell factories.
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Engineering Regioselectivity of a P450 Monooxygenase Enables the Synthesis of Ursodeoxycholic Acid via 7β-Hydroxylation of Lithocholic Acid
Sascha Grobe,Christoffel P. S. Badenhorst,Thomas Bayer,Emil Hamnevik,Shuke Wu,Christoph W. Grathwol,Andreas Link,Sven Koban,Henrike Brundiek,Beatrice Großjohann,Uwe T. Bornscheuer +10 more
TL;DR: A nearly perfectly regio‐ and stereoselective triple mutant (F84Q/S240A/V291G) that produces 10‐fold higher levels of UDCA than the S240A variant is identified, which opens up new possibilities for the environmentally friendly synthesis of UD CA from the biological waste product LCA.
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Biocompatible metal-assisted C–C cross-coupling combined with biocatalytic chiral reductions in a concurrent tandem cascade
Patricia Schaaf,Thomas Bayer,Moumita Koley,Michael Schnürch,Uwe T. Bornscheuer,Florian Rudroff,Marko D. Mihovilovic +6 more
TL;DR: A concurrent chemo/biocatalytic one pot reaction cascade by combining a metal (Pd/Cu) assisted Liebeskind-Srogl (L-S) coupling with an enantioselective enzymatic reduction for the production of chiral amines and alcohols is presented.
Journal ArticleDOI
Modifikation der Regioselektivität einer P450-Monooxygenase ermöglicht die Synthese von Ursodeoxycholsäure durch die 7β-Hydroxylierung von Lithocholsäure
Sascha Grobe,Christoffel P. S. Badenhorst,Thomas Bayer,Emil Hamnevik,Shuke Wu,Christoph W. Grathwol,Andreas Link,Sven Koban,Henrike Brundiek,Beatrice Großjohann,Uwe T. Bornscheuer +10 more