Thomas-Benjamin Seiler

TL;DR: Current experience with the EDA approach and the tools required are summarized, and practical advice on their application is provided, highlighting the need for proper problem formulation and giving general advice for study design.

TL;DR: The vision of the international, EU-funded project SOLUTIONS is described, where three routes are explored to link the occurrence of chemical mixtures at specific sites to the assessment of adverse biological combination effects, and comprehensive arrays of effect-based tools and trait-based field observations are explored.

TL;DR: An optimized method that considers the frequency of concentrations above predicted no effects levels was developed on the basis of the traditional method, and it was then used to identify and screen candidate priority pollutants in European surface waters and proved the feasibility and advantages of the optimized method.

TL;DR: The utility of fingerprinting single chemicals for an improved understanding of the biological effect of pollutants is demonstrated, and the need to apply bioassays for water quality monitoring is highlighted in order to prevent underestimation of the overall biological effect.

TL;DR: The importance of fingerprinting the effects of detected chemicals is highlighted, as they explain less than 0.2% of the biological effect in the PXR activation, adaptive stress response, and fish embryo toxicity assays.