T
Thomas D. Bird
Researcher at University of Washington
Publications - 756
Citations - 47823
Thomas D. Bird is an academic researcher from University of Washington. The author has contributed to research in topics: GeneReviews & Medicine. The author has an hindex of 98, co-authored 738 publications receiving 44242 citations. Previous affiliations of Thomas D. Bird include Harborview Medical Center & Rush University Medical Center.
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Journal ArticleDOI
Candidate gene for the chromosome 1 familial Alzheimer's disease locus
Ephrat Levy-Lahad,Wilma Wasco,Parvoneh Poorkaj,Donna M. Romano,Junko Oshima,Warren H. Pettingell,Chang En Yu,P. D. Jondro,Stephen D. Schmidt,Kai Wang,Annette C. Crowley,Ying-Hui Fu,Suzanne Y. Guénette,David J. Galas,Ellen Nemens,Ellen M. Wijsman,Thomas D. Bird,Gerard D. Schellenberg,Rudolph E. Tanzi +18 more
TL;DR: The presence of missense mutations in AD subjects in two highly similar genes strongly supports the hypothesis that mutations in both are pathogenic.
Journal ArticleDOI
Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease.
D. Scheuner,Christopher B. Eckman,Christopher B. Eckman,Malene Jensen,X. Song,Martin Citron,Nobuhiro Suzuki,Thomas D. Bird,John Hardy,Mike Hutton,Walter A. Kukull,Eric Larson,Ephrat Levy-Lahad,Matti Viitanen,Elaine R. Peskind,Parvoneh Poorkaj,Gerard D. Schellenberg,Rudolph E. Tanzi,Wilma Wasco,Lars Lannfelt,Dennis J. Selkoe,Steven G. Younkin +21 more
TL;DR: The findings indicate that the FAD–linked mutations may all cause Alzheimer's disease by increasing the extracellular concentration of Aβ42(43), thereby fostering cerebral deposition of this highly amyloidogenic peptide.
Journal ArticleDOI
Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease.
Adam C. Naj,Gyungah Jun,Gary W. Beecham,Li-San Wang,Badri N. Vardarajan,Jacqueline L. Buros,Paul Gallins,Joseph D. Buxbaum,Gail P. Jarvik,Paul K. Crane,Eric B. Larson,Thomas D. Bird,Bradley F. Boeve,Neill R. Graff-Radford,Philip L. De Jager,Philip L. De Jager,Denis A. Evans,Julie A. Schneider,Minerva M. Carrasquillo,Nilufer Ertekin-Taner,Steven G. Younkin,Carlos Cruchaga,John S. K. Kauwe,Petra Nowotny,Patricia L. Kramer,John Hardy,Matthew J. Huentelman,Amanda J. Myers,M. Michael Barmada,F. Yesim Demirci,Clinton T. Baldwin,Robert C. Green,Ekaterina Rogaeva,Peter St George-Hyslop,Peter St George-Hyslop,Steven E. Arnold,Robert W Barber,Thomas H. Beach,Eileen H. Bigio,James D. Bowen,Adam L. Boxer,James R. Burke,Nigel J. Cairns,Christopher S. Carlson,Regina M. Carney,Steven L. Carroll,Helena C. Chui,David G. Clark,Jason J. Corneveaux,Carl W. Cotman,Jeffrey L. Cummings,Charles DeCarli,Steven T. DeKosky,Ramon Diaz-Arrastia,Malcolm B. Dick,Dennis W. Dickson,William G. Ellis,Kelley Faber,Kenneth B. Fallon,Martin R. Farlow,Steven H. Ferris,Matthew P. Frosch,Douglas Galasko,Mary Ganguli,Marla Gearing,Daniel H. Geschwind,Bernardino Ghetti,John R. Gilbert,Sid Gilman,Bruno Giordani,Jonathan D. Glass,John H. Growdon,Ronald L. Hamilton,Lindy E. Harrell,Elizabeth Head,Lawrence S. Honig,Christine M. Hulette,Bradley T. Hyman,Gregory A. Jicha,Lee-Way Jin,Nancy Johnson,Jason Karlawish,Anna Karydas,Jeffrey Kaye,Ronald C. Kim,Edward H. Koo,Neil W. Kowall,James J. Lah,Allan I. Levey,Andrew P. Lieberman,Oscar L. Lopez,Wendy J. Mack,Daniel C. Marson,Frank Martiniuk,Deborah C. Mash,Eliezer Masliah,Wayne C. McCormick,Susan M. McCurry,Andrew McDavid,Ann C. McKee,W Marsel Mesulam,Bruce L. Miller,Carol A. Miller,Joshua W. Miller,Joseph E. Parisi,Daniel P. Perl,Elaine R. Peskind,Ronald C. Petersen,Wayne W. Poon,Joseph F. Quinn,Ruchita Rajbhandary,Murray A. Raskind,Barry Reisberg,John M. Ringman,Erik D. Roberson,Roger N. Rosenberg,Mary Sano,Lon S. Schneider,William P. Seeley,Michael L. Shelanski,Michael A. Slifer,Charles D. Smith,Joshua A. Sonnen,Salvatore Spina,Robert S. Stern,Rudolph E. Tanzi,John Q. Trojanowski,Juan C. Troncoso,Vivianna M. Van Deerlin,Harry V. Vinters,Jean Paul Vonsattel,Sandra Weintraub,Kathleen A. Welsh-Bohmer,Jennifer Williamson,Randall L. Woltjer,Laura B. Cantwell,Beth A. Dombroski,Duane Beekly,Kathryn L. Lunetta,Eden R. Martin,M. Ilyas Kamboh,Andrew J. Saykin,Eric M. Reiman,David A. Bennett,John C. Morris,Thomas J. Montine,Alison Goate,Deborah Blacker,Debby W. Tsuang,Hakon Hakonarson,Walter A. Kukull,Tatiana Foroud,Jonathan L. Haines,Richard Mayeux,Margaret A. Pericak-Vance,Lindsay A. Farrer,Gerard D. Schellenberg +156 more
TL;DR: The Alzheimer Disease Genetics Consortium performed a genome-wide association study of late-onset Alzheimer disease using a three-stage design consisting of a discovery stage (stage 1), two replication stages (stages 2 and 3), and both joint analysis and meta-analysis approaches were used.
Journal ArticleDOI
Tau is a candidate gene for chromosome 17 frontotemporal dementia.
Parvoneh Poorkaj,Thomas D. Bird,Ellen M. Wijsman,Ellen Nemens,Ralph M. Garruto,Leojean Anderson,Athena Andreadis,W. C. Wiederholt,Murray A. Raskind,Gerard D. Schellenberg +9 more
TL;DR: Three lines of evidence indicate that the Val279Met change is an FTDP‐17 causative mutation, and normal valine is found at this position in all three tau interrepeat sequences and in other microtubule associated protein tau homologues.
Journal ArticleDOI
Mutation-Specific Functional Impairments in Distinct Tau Isoforms of Hereditary FTDP-17
Ming Hong,Victoria Zhukareva,Vanessa Vogelsberg-Ragaglia,Zbigniew K. Wszolek,Lee Reed,Bruce I. Miller,Daniel H. Geschwind,Thomas D. Bird,Daniel W. McKeel,Alison Goate,John C. Morris,Kirk C. Wilhelmsen,Gerard D. Schellenberg,John Q. Trojanowski,Virginia M.-Y. Lee +14 more
TL;DR: Functional assays of recombinant tau proteins with different FTDP-17 missense mutations implicated all but one of these mutations in disease pathogenesis by reducing the ability of tau to bind microtubules and promote microtubule assembly.