T
Thomas G. Brott
Researcher at Mayo Clinic
Publications - 299
Citations - 48040
Thomas G. Brott is an academic researcher from Mayo Clinic. The author has contributed to research in topics: Stroke & Carotid endarterectomy. The author has an hindex of 83, co-authored 284 publications receiving 44826 citations. Previous affiliations of Thomas G. Brott include American Heart Association & New York State Department of Health.
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Journal ArticleDOI
Tissue plasminogen activator for acute ischemic stroke. The National Institute of Neurological Disorders and Stroke rt-PA Stroke Study Group.
James C. Grotta,M Kothari,K.M.A. Welch,Joseph P. Broderick,Barbara C. Tilley,Thomas G. Brott,Marler,Patrick D. Lyden,Paul M. O'Byrne +8 more
Journal ArticleDOI
Association of outcome with early stroke treatment: pooled analysis of ATLANTIS, ECASS, and NINDS rt-PA stroke trials
Werner Hacke,Geoffrey A. Donnan,Cesare Fieschi,Markku Kaste,Rüdiger von Kummer,Joseph P. Broderick,Thomas G. Brott,Michael Frankel,James C. Grotta,E. Clarke Haley,Thomas Kwiatkowski,Steven R. Levine,Chris Lewandowski,Mei Lu,Patrick D. Lyden,John R. Marler,Suresh C. Patel,Barbara C. Tilley,Gregory W. Albers,Erich Bluhmki,Manfred Wilhelm,Scott Hamilton,Atlantis Trials Investigators,Ecass Trials Investigators +23 more
TL;DR: The sooner that rt-PA is given to stroke patients, the greater the benefit, especially if started within 90 min, which suggests a potential benefit beyond 3 h, but this potential might come with some risks.
Journal ArticleDOI
Stenting versus Endarterectomy for Treatment of Carotid-Artery Stenosis
Thomas G. Brott,Thomas G. Brott,Robert W. Hobson,George Howard,Gary S. Roubin,Wayne M. Clark,William H. Brooks,Ariane Mackey,Michael D. Hill,Pierre P. Leimgruber,Alice J. Sheffet,Virginia J. Howard,Wesley S. Moore,Jenifer H. Voeks,L. Nelson Hopkins,Donald E. Cutlip,David J. Cohen,Jeffrey J. Popma,Robert D. Ferguson,Stanley N. Cohen,Joseph L. Blackshear,Frank L. Silver,J. P. Mohr,Brajesh K. Lal,James F. Meschia +24 more
TL;DR: Among patients with symptomatic or asymptomatic carotid stenosis, the risk of the composite primary outcome of stroke, myocardial infarction, or death did not differ significantly in the group undergoing carotids-artery stenting and the group undergoes carOTid endarterectomy.
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Time to treatment with intravenous alteplase and outcome in stroke: an updated pooled analysis of ECASS, ATLANTIS, NINDS, and EPITHET trials.
Kennedy R. Lees,Erich Bluhmki,Rüdiger von Kummer,Thomas G. Brott,Danilo Toni,James C. Grotta,Gregory W. Albers,Markku Kaste,John R. Marler,Scott Hamilton,Barbara C. Tilley,Stephen M. Davis,Geoffrey A. Donnan,Werner Hacke +13 more
TL;DR: Patients with ischaemic stroke selected by clinical symptoms and CT benefit from intravenous alteplase when treated up to 4.5 h should be taken to shorten delay in initiation of treatment to increase benefit to a maximum.
Journal ArticleDOI
Updated Standardized Endpoint Definitions for Transcatheter Aortic Valve Implantation
A. Pieter Kappetein,Stuart J. Head,Philippe Généreux,Nicolo Piazza,Nicolas M. Van Mieghem,Eugene H. Blackstone,Thomas G. Brott,David Cohen,Donald E. Cutlip,Gerrit-Anne van Es,Rebecca T. Hahn,Ajay J. Kirtane,Mitchell W. Krucoff,Susheel Kodali,Michael J. Mack,Roxana Mehran,Josep Rodés-Cabau,Pascal Vranckx,John G. Webb,Stephan Windecker,Patrick W. Serruys,Martin B. Leon +21 more
TL;DR: This VARC-2 document has provided further standardization of endpoint definitions for studies evaluating the use of TAVI, which will lead to improved comparability and interpretability of the study results, supplying an increasingly growing body of evidence with respect to TAVi and/or surgical aortic valve replacement.