Thomas H. Doyne

Bio: Thomas H. Doyne is an academic researcher from Villanova University. The author has contributed to research in topics: Crystal structure & Nylon 4. The author has an hindex of 3, co-authored 3 publications receiving 61 citations.

The Crystal Structure of a Diacid Triglyceride

Abstract: The x-ray structure analysis of a single crystal of the β-@#@ form of 2-11-bromoundecanoyl-l, 1- dicaprin has revealed an arrangement of carbon atom chains within a molecular layer that is identical to that found in the β-form monoacid triglycerides. However the packing of the molec-ular layers within the crystal lattice is sub-stantially different because of the unequal fatty acid chain-lengths in the symmetrical diacid triglyceride of this investigation.

Crystallographic studies of nylon 4. I. Determination of the crystal structure of the α polymorph of nylon 4

Abstract: The crystal structure of the α polymorph of nylon 4 has been determined from the x-ray diffraction patterns of uniaxially oriented monofilaments. In general the crystal structure of α nylon 4 is similar to that of α nylon 6. The unit cell is monoclinic with the following dimensions: a = 9.29 ± 0.05 A., b = 12.24 ± 0.05 A., c = 7.97 ± 0.05 A., and β = 114.5 ± 1.0°. There are eight monomeric units in the unit cell. The theoretical density is 1.37 g./cc. and the observed density 1.25 g./cc. The space group is P21. The nylon 4 chains are of the extended planar zigzag type, with the plane of the zigzag approximately parallel to the a axis of the unit cell. Along the a axis, every other chain is inverted—an antiparallel arrangement of chains—thus permitting complete hydrogen bonding and the formation of sheets of nylon 4 chains. Along the c axis of the unit cell, the second sheet is displaced by3/10 of the b axis, thus leading to a staggered arrangement of sheets. The sheets are held in place by van der Waals forces.

Crystallographic studies of nylon 4. II. On the β and δ polymorphs of nylon 4

Abstract: In addition to the α polymorph, two crystalline forms of nylon 4, the β and δ polymorphs, have been observed and studied. The β polymorph of nylon 4, which has not been found in a pure condition, appears to be similar to the β polymorph of nylon 6. The extended planar zigzag conformation of chains, found in the α polymorph, is present also in the β polymorph. Three models have been proposed to explain the observed data. In model 1, the staggered shear of van der Waals bonded sheets found in the α polymorph is abandoned; in model 2, the sheets are displaced by 1/2 the b axis, and in model 3 the chains are arranged in a parallel array. The β polymorph is converted to the α form in air upon heating for 11 min. at 227°C. and upon immersion in water for 2 hr. Models 1 and 2 would be converted to the α polymorph by a slippage of the van der Waals bonded sheets while the conversion from model 3 would involve a rupture of hydrogen bonds, a rotation of the chains through 90°, and the reformation of hydrogen bonds. The δ polymorph is formed by rapidly quenching extruded nylon 4 against chilled rolls. It is a metastable form which has only been observed in an unoriented condition. Upon orientation it is completely converted to the α polymorph. In addition to this, its conversion to the α form occurs under conditions similar to the β–α transition. The observed diffraction pattern can be indexed on the basis of a hexagonal packing of chains. High-temperature x-ray diffraction studies of the α polymorph suggest that the δ form, or a structure similar to it, is the high-temperature form of nylon 4.

Crystal Structures and Properties of Nylon Polymers from Theory

Abstract: A complete force field (MSXX) for simulation of all nylon polymers is derived from ab initio quantum calculations. Special emphasis is given to the accuracy of the hydrogen bond potential for the amide unit and the torsional potential between the peptide and alkane fragments. The MSXX force field was used to predict the structures, moduli, and detailed geometries of all nine nylons for which there are experimental crystal data plus one other. For nylon-(2n) with 2n ≤ 6, the α crystal structure (with all-trans CH2 chains nearly coplanar with the hydrogen bonding plane) is more stable, while for 2n > 6, γ (with the alkane plane twisted by 70°) is more stable. This change results from the increased importance of methylene packing interactions over H bonds for larger 2n. We find the highest Young's modulus for nylon-7.

Molecular Arrangement in Glycerides

Abstract: The main features of glyceride crystallization are discussed on the basis of earlier known crystal structures of glycerides and the new results, particularly on their structure in the liquid state. An analysis of the methyl end group packing is presented, which enables to predict whether a particular crystal form of a mixed triglyceride exists. It is also demonstrated, how these basic informations can be used in order to obtain the molecular conformation from powder data, and this is illustrated in the case of a 2-oleo-disaturated glyceride. Molekulare Anordnung der Glyceride An Hand der fruheren Erkenntnisse uber die Kristallstruktur der Glyceride sowie der neueren Ergebnisse, insbesondere hinsichtlich ihrer Struktur im flussigen Zustand, werden die Hauptmerkmale der Kristallisation von Glyceriden diskutiert. Die beschriebene Analyse der Packung der Methyl-Endgruppe ermoglicht es, vorauszusagen, ob eine bestimmte Kristallform eines gemischten Triglycerids vorliegt. Es wird auch dargestellt, inwiefern diese Grundkenntnisse zur Ermittlung der molekularen Anordnung aus den Daten der Pulver-Diagramme eingesetzt werden konnen; als Beispiel wurde ein 2-Oleo-digesattigtes Glycerid gewahlt.

γ2‐, γ3‐, and γ2,3,4‐Amino Acids, Coupling to γ‐Hexapeptides: CD Spectra, NMR Solution and X‐ray Crystal Structures of γ‐Peptides

Abstract: There are numerous possible γ-amino acids with different degrees of substitution and with various constitutions and configurations Of these the γ4- and the like- and unlike-γ2,4-amino acids have been previously used as building blocks in γ-peptides The synthesis of γ2-, γ3-, and γ2,3,4-peptides is now described The corresponding amino acids have been prepared by Michael addition of chiral N-acyl-oxazolidinone enolates to nitro-olefins, with subsequent reduction of the NO2 to NH2 groups Such additions to E-2-methyl-nitropropene provide (2R,3R,4R)-2-alkyl-3-methyl-4-amino-pentanoic acid derivatives (9, 10, 11) Stepwise coupling and fragment coupling lead to γ-di-, tri-, and hexapeptides (12–23), which were fully characterized The crystal structures of one of the γ-amino acids (2,3-dimethyl-4-amino-pentanoic acid⋅HCl, 9 a), of a γ2,3,4-di- and a γ2,3,4-tetrapeptide (20, 22) are described, and the NMR solution structure in MeOH of a γ2,3,4-hexapeptide (3) has been determined (using TOCSY, COSY, HSQC, HMBC and ROESY measurements and a molecular dynamics simulated-annealing protocol) A linear conformation (sheet-like), a novel (M) helix built of nine-membered hydrogen-bonded rings, and (M) 2614 helices have thus been identified NMR measurements at different temperatures (298–393 K) and H/D-exchange rates obtained for the γ2,3,4-hexapeptide are interpreted as evidence for the stability of the 2614 helix (no “melting”) and for its non-cooperative folding mechanism CD Spectra of the γ-peptides have been measured in MeOH and CH3CN, indicating that only the protected and unprotected γ2,3,4-hexapeptide is present as the 2614 helix in solution The structures of the γ2- and γ3-hexapeptides (1, 2) could not be determined