Thomas Henle

TL;DR: Concentrations of retention solutes in uremia vary over a broad range, from nanograms per liter to grams per liter, and a substantial number of molecules are protein bound and/or middle molecules, and many of these exert toxicity and are characterized by a high range of toxic over normal concentration (CU/CN ratio).

TL;DR: Data demonstrate that ligands of RAGE can induce sustained activation of NF-kappaB as a result of increased levels of de novo synthesized NF-KappaBp65 overriding endogenous negative feedback mechanisms and thus might contribute to the persistent NF- kappaB activation observed in hyperglycemia and possibly other chronic diseases.

TL;DR: For six samples of New Zealand Manuka (Leptospermum scoparium) honey very high amounts of MGO were found, ranging from 38 to 761 mg/kg, which is up to 100-fold higher compared to conventional honeys, which clearly demonstrates that the pronounced antibacterial activity of NewNZ Manuka honey directly originates from MGO.

TL;DR: This Review gives an overview of the most important discoveries in Maillard research since it was first described and shows that the complex reaction, even after over one hundred years, has lost none of its interdisciplinary actuality.

TL;DR: 1,2-dicarbonyl compounds, formed from carbohydrates during thermal processing in the course of caramelization and Maillard reactions, are intensively discussed as precursors for advanced glycation endproducts in foods and in vivo.