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Thomas J. Begley

Researcher at University at Albany, SUNY

Publications -  92
Citations -  14384

Thomas J. Begley is an academic researcher from University at Albany, SUNY. The author has contributed to research in topics: Transfer RNA & DNA damage. The author has an hindex of 37, co-authored 84 publications receiving 12317 citations. Previous affiliations of Thomas J. Begley include Massachusetts Institute of Technology & State University of New York System.

Papers
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Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

Daniel J. Klionsky, +2522 more
- 21 Jan 2016 - 
TL;DR: In this paper, the authors present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macro-autophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.
Journal ArticleDOI

Guidelines for the use and interpretation of assays for monitoring autophagy

Daniel J. Klionsky, +1287 more
- 01 Apr 2012 - 
TL;DR: These guidelines are presented for the selection and interpretation of methods for use by investigators who aim to examine macroautophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.
Journal ArticleDOI

A Quantitative Systems Approach Reveals Dynamic Control of tRNA Modifications during Cellular Stress

Clement T Y Chan, +5 more
- 16 Dec 2010 - 
TL;DR: In this paper, a mass spectrometric method was developed to quantify tRNA modifications in Saccharomyces cerevisiae and revealed several novel biosynthetic pathways for RNA modifications and led to the discovery of signature changes in the spectrum of tRN modifications in the damage response to mechanistically different toxicants.
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Reprogramming of tRNA modifications controls the oxidative stress response by codon-biased translation of proteins

Clement T Y Chan, +6 more
- 03 Jul 2012 - 
TL;DR: Proteomic analysis reveals that oxidative stress causes a significant translational bias toward proteins coded by TTG-enriched genes, which points to stress-induced reprogramming of tRNA modifications and consequential reprograming of ribosomes in translational control of cell survival.
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Trm9-catalyzed tRNA modifications link translation to the DNA damage response.

Ulrike Begley, +8 more
- 14 Dec 2007 - 
TL;DR: It is proposed that Trm9-specific tRNA modifications enhance codon-specific translation elongation and promote increased levels of key damage response proteins.