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Thomas J. Daly
Researcher at Regeneron
Publications - 39
Citations - 5239
Thomas J. Daly is an academic researcher from Regeneron. The author has contributed to research in topics: Fusion protein & Vascular endothelial growth factor. The author has an hindex of 17, co-authored 39 publications receiving 4939 citations. Previous affiliations of Thomas J. Daly include Beth Israel Deaconess Medical Center.
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Journal ArticleDOI
Angiopoietin-2, a Natural Antagonist for Tie2 That Disrupts in vivo Angiogenesis
Maisonpierre Peter C,Chitra Suri,Pamela F. Jones,Sona Bartunkova,Stanley J. Wiegand,Czeslaw Radziejewski,Debra L Compton,Joyce Mcclain,Aldrich Thomas H,Nick Papadopoulos,Thomas J. Daly,Samuel Davis,Thomas N. Sato,George D. Yancopoulos +13 more
TL;DR: The discovery of a negative regulator acting on Tie2 emphasizes the need for exquisite regulation of this angiogenic receptor system.
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Cytokine traps: multi-component, high-affinity blockers of cytokine action
Aris N. Economides,Laura Rocco Carpenter,John S. Rudge,Vivien Wong,Ellen M. Koehler-Stec,Christopher Hartnett,Erica Pyles,Xiaobing Xu,Thomas J. Daly,Michael R. Young,James P. Fandl,Frank Lee,Scott Carver,Jennifer McNay,Kevin Bailey,Swayampakula Ramakanth,Renta Hutabarat,Tammy T. Huang,Czeslaw Radziejewski,George D. Yancopoulos,Neil Stahl +20 more
TL;DR: A generally applicable method to create very high-affinity blockers called 'cytokine traps' consisting of fusions between the constant region of IgG and the extracellular domains of two distinct cytokine receptor components involved in binding the cytokine.
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Angiopoietin-2 functions as an autocrine protective factor in stressed endothelial cells.
Christopher Daly,Elizabeth Pasnikowski,Elena Burova,Vivian Wong,Aldrich Thomas H,Jennifer A. Griffiths,Ella Ioffe,Thomas J. Daly,James P. Fandl,Nick Papadopoulos,Donald M. McDonald,Gavin Thurston,George D. Yancopoulos,John S. Rudge +13 more
TL;DR: It is demonstrated that Ang-2 expression is rapidly induced in endothelial cells by the transcription factor FOXO1 after inhibition of the phosphatidylinositol 3-kinase/Akt pathway, which suggests a model in which Ang-1 acts as an autocrine Tie2 agonist and protective factor.
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Angiopoietins have distinct modular domains essential for receptor binding, dimerization and superclustering
Samuel Davis,Nick Papadopoulos,Aldrich Thomas H,Maisonpierre Peter C,Tammy T. Huang,Lubomir Kovac,April Xu,Raymond W. Leidich,Elzbieta Radziejewska,Ashique Rafique,Judah Goldberg,Vivek Jain,Kevin Bailey,Margaret Karow,Jim Fandl,Steven Samuelsson,Ella Ioffe,John S. Rudge,Thomas J. Daly,Czeslaw Radziejewski,George D. Yancopoulos +20 more
TL;DR: It is shown that angiopoietin-1 has a modular structure unlike any previously characterized growth factor, and its antagonist activity seems to be a subtle property encoded in its receptor-binding domain.
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Dietary saturated fatty acids down-regulate cyclooxygenase-2 and tumor necrosis factor alfa and reverse fibrosis in alcohol-induced liver disease in the rat
Amin A. Nanji,David Zakim,Amir Rahemtulla,Thomas J. Daly,Lili Miao,Shuping Zhao,Shamsuddin Khwaja,Steven R. Tahan,Andrew J. Dannenberg +8 more
TL;DR: The data indicate that a diet enriched in saturated fatty acids effectively reverses alcohol‐induced liver injury, including fibrosis, and may be explained, at least in part, by reduced endotoxemia and lipid peroxidation, which in turn result in decreased levels of TNF‐α and Cox‐2.