T
Thomas J. Simpson
Researcher at University of Bristol
Publications - 275
Citations - 8564
Thomas J. Simpson is an academic researcher from University of Bristol. The author has contributed to research in topics: Polyketide & Polyketide synthase. The author has an hindex of 47, co-authored 272 publications receiving 7855 citations. Previous affiliations of Thomas J. Simpson include University of Edinburgh & Australian National University.
Papers
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Journal ArticleDOI
Meroterpenoids produced by fungi
Regina Geris,Thomas J. Simpson +1 more
TL;DR: This review deals with the isolation and structure elucidation of meroterpenoids from higher and lower fungi, and discusses biosynthetic studies and biological activities as appropriate.
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A chain initiation factor common to both modular and aromatic polyketide synthases
Christian Bisang,Paul F. Long,Jesus Cortes,James Westcott,John Crosby,Anne-Lise Matharu,Russell J. Cox,Thomas J. Simpson,James Staunton,Peter F. Leadlay +9 more
TL;DR: It is shown that a component of aromatic PKS, previously named ‘chain-length factor’, is a factor required for polyketide chain initiation and that this factor has decarboxylase activity towards malonyl-ACP (acyl carrier protein).
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Characterization of the Mupirocin Biosynthesis Gene Cluster from Pseudomonas fluorescens NCIMB 10586
A. Kassem El-Sayed,Joanne Hothersall,Sian M. Cooper,Elton R. Stephens,Thomas J. Simpson,Christopher M. Thomas +5 more
TL;DR: A model for mupirocin biosynthesis is presented based on the sequence and biochemical evidence, andGene knockout experiments demonstrated the importance of regions in m upirocin production, and complementation of the disrupted gene confirmed that the phenotypes were not due to polar effects.
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An antibiotic produced by an insect-pathogenic bacterium suppresses host defenses through phenoloxidase inhibition.
Ioannis Eleftherianos,Sam Boundy,Susan A. Joyce,Shazia N. Aslam,James W. Marshall,Russell J. Cox,Thomas J. Simpson,David Clarke,Richard H. ffrench-Constant,Stuart E. Reynolds +9 more
TL;DR: Photorhabdus produces a small-molecule antibiotic that also acts as an inhibitor of phenoloxidase (PO) in the insect host Manduca sexta, which has a dual function both as a PO inhibitor to counter host immune reactions and also as an antibiotic to exclude microbial competitors from the insect cadaver.
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Fusarin C Biosynthesis in Fusarium moniliforme and Fusarium venenatum
TL;DR: Targeted gene disruption produced a fusarin‐deficient strain of F. venenatum, thereby proving that this synthase is responsible for the first steps offusarin biosynthesis.