T
Thomas L. Shirley
Researcher at University at Albany, SUNY
Publications - 3
Citations - 644
Thomas L. Shirley is an academic researcher from University at Albany, SUNY. The author has contributed to research in topics: Huntingtin & Huntingtin Protein. The author has an hindex of 3, co-authored 3 publications receiving 610 citations. Previous affiliations of Thomas L. Shirley include New York State Department of Health.
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Journal ArticleDOI
Msh2 deficiency prevents in vivo somatic instability of the CAG repeat in Huntington disease transgenic mice.
Kevin Manley,Thomas L. Shirley,Thomas L. Shirley,Lorraine Flaherty,Lorraine Flaherty,Anne Messer,Anne Messer +6 more
TL;DR: The results show that Msh2 is required for somatic instability of the HD CAG repeat, suggesting important functional correlations between repeat length and pathology.
Journal ArticleDOI
Human single-chain Fv intrabodies counteract in situ huntingtin aggregation in cellular models of Huntington's disease.
Jean-Michel Lecerf,Thomas L. Shirley,Quan Zhu,Aleksey G. Kazantsev,Peter Amersdorfer,David E. Housman,Anne Messer,James S. Huston +7 more
TL;DR: This study suggests that intrabody-mediated modulation of abnormal neuronal proteins may contribute to the treatment of neurodegenerative diseases such as HD, Alzheimer's, Parkinson's, prion disease, and the spinocerebellar ataxias.
Journal ArticleDOI
DNA vaccination against mutant huntingtin ameliorates the HDR6/2 diabetic phenotype.
TL;DR: Observations suggest that DNA vaccination against toxic intracellular proteins may be therapeutic and demonstrate that HDR6/2 diabetes may be caused by a severe pancreatic insulin deficiency.