Thomas M. Houslay

TL;DR: It is demonstrated how alternative approaches enable behavioural ecologists to test hypotheses about the causes and consequences of individual behavioural variation while accounting for the uncertainty inherent in the random effects.

TL;DR: The utility of a cell-based assay and custom designed image analysis algorithms designed to monitor morphologic phenotypic response in detail across distinct cancer cell types are shown and have the potential to drive the development of a new generation of novel therapeutic classes encompassing pharmacologic compositions or polypharmacology in appropriate disease context.

TL;DR: The data show that the interaction of PDE4D5 with both the N- and C-domains of beta-arrestin 2 are essential for beta2-AR regulation.

TL;DR: PDE4A11 is a novel, widely expressed long isoform that is activated by PKA phosphorylation and shows a distinct intracellular localization, indicating that it may contribute to compartmentalized cAMP signaling in cells in which it is expressed.

TL;DR: It is shown that a multivariate approach to assessing changes in among‐individual behaviouralvariance across contexts can prevent the over‐interpretation of statistically significant, but small, individual‐by‐environment effects.