T
Thomas Perlmann
Researcher at Karolinska Institutet
Publications - 128
Citations - 16907
Thomas Perlmann is an academic researcher from Karolinska Institutet. The author has contributed to research in topics: Dopaminergic & Retinoid X receptor. The author has an hindex of 59, co-authored 122 publications receiving 15792 citations. Previous affiliations of Thomas Perlmann include Ludwig Institute for Cancer Research & Salk Institute for Biological Studies.
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Journal ArticleDOI
An Orphan Nuclear Receptor Activated by Pregnanes Defines a Novel Steroid Signaling Pathway
Steven A. Kliewer,John T. Moore,Laura E. Wade,Jeff L. Staudinger,Michael A. Watson,Stacey A. Jones,David D. McKee,Beverly B. Oliver,Timothy M. Willson,Rolf Zetterström,Thomas Perlmann,Jürgen M. Lehmann +11 more
TL;DR: The results provide evidence for the existence of a novel steroid hormone signaling pathway with potential implications in the regulation of steroid hormone and sterol homeostasis and the expression of the CYP3A family of steroid hydroxylases and modulates sterol and bile acid biosynthesis in vivo.
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Identification of a nuclear receptor that is activated by farnesol metabolites
Barry M. Forman,Elizabeth Goode,Jasmine Chen,Anthony E. Oro,David J. Bradley,Thomas Perlmann,Daniel J. Noonan,Leo T. Burka,Trevor C. McMorris,William W Lamph,Ronald M. Evans,Cary Weinberger +11 more
TL;DR: The results suggest that metabolite-controlled intracellular signaling systems are utilized by higher organisms as transcriptional regulators in bacteria and yeast.
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Dopamine neuron agenesis in Nurr1-deficient mice.
Rolf Zetterström,Ludmila Solomin,Ludmila Solomin,Ludmila Solomin,Lottie Jansson,Lottie Jansson,Lottie Jansson,B. Hoffer,B. Hoffer,B. Hoffer,Lars Olson,Lars Olson,Lars Olson,Thomas Perlmann,Thomas Perlmann,Thomas Perlmann +15 more
TL;DR: Results suggest that putative Nurr1 ligands may be useful for treatment of Parkinson's disease and other disorders of midbrain dopamine circuitry.
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Docosahexaenoic Acid, a Ligand for the Retinoid X Receptor in Mouse Brain
Alexander Mata de Urquiza,Suya Liu,Maria Sjöberg,Rolf Zetterström,William J. Griffiths,Jan Sjövall,Thomas Perlmann +6 more
TL;DR: DHA, a long-chain polyunsaturated fatty acid that is highly enriched in the adult mammalian brain, is identified as a factor in brain tissue from adult mice that activates RXR in cell-based assays, suggesting that DHA may influence neural function through activation of an RXR signaling pathway.
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Identification of Intrinsic Determinants of Midbrain Dopamine Neurons
Elisabet Andersson,Ulrika Tryggvason,Qiaolin Deng,Stina Friling,Zhanna Alekseenko,Benoît Robert,Thomas Perlmann,Thomas Perlmann,Johan Ericson +8 more
TL;DR: It is shown that the homeodomain proteins Lmx1a and Msx1 function as determinants of midbrain dopamine neurons, cells that degenerate in patients with Parkinson's disease, and suggest that they may be essential tools in cell replacement strategies in Parkinson’s disease.