T
Thomas Ried
Researcher at National Institutes of Health
Publications - 401
Citations - 34909
Thomas Ried is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Comparative genomic hybridization & Cancer. The author has an hindex of 90, co-authored 384 publications receiving 32851 citations. Previous affiliations of Thomas Ried include University of Göttingen & Heidelberg University.
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Journal ArticleDOI
Multicolor Spectral Karyotyping of Human Chromosomes
Evelin Schröck,S du Manoir,T Veldman,B Schoell,Johannes Wienberg,Malcolm A. Ferguson-Smith,Yi Ning,David H. Ledbetter,Irit Bar-Am,D. Soenksen,Yuval Garini,Thomas Ried +11 more
TL;DR: Whole-genome scanning by spectral karyotyping allowed instantaneous visualization of defined emission spectra for each human chromosome after fluorescence in situ hybridization, and all human chromosomes were simultaneously identified.
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Atm-deficient mice: a paradigm of ataxia telangiectasia.
Carrolee Barlow,Shinji Hirotsune,Richard Paylor,Marek Liyanage,Michael Eckhaus,Francis J Collins,Yosef Shiloh,Jacqueline N. Crawley,Thomas Ried,Danilo A. Tagle,Anthony Wynshaw-Boris +10 more
TL;DR: Atm-disrupted mice recapitulate the ataxia telangiectasia phenotype in humans, providing a mammalian model in which to study the pathophysiology of this pleiotropic disorder.
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SIRT6 is a histone H3 lysine 9 deacetylase that modulates telomeric chromatin
Eriko Michishita,Ronald A. McCord,Elisabeth Berber,Mitomu Kioi,Hesed Padilla-Nash,Mara Damian,Peggie Cheung,Rika Kusumoto,Tiara L.A. Kawahara,J. Carl Barrett,Howard Y. Chang,Vilhelm A. Bohr,Thomas Ried,Or Gozani,Katrin F. Chua +14 more
TL;DR: The human SIRT6 protein is an NAD+-dependent, histone H3 lysine 9 (H3K9) deacetylase that modulates telomeric chromatin and contributes to the propagation of a specialized chromatin state at mammalian telomeres, which in turn is required for proper telomere metabolism and function.
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Centrosome amplification and a defective G2-M cell cycle checkpoint induce genetic instability in BRCA1 exon 11 isoform-deficient cells.
Xiaoling Xu,Zoë Weaver,Steven P. Linke,Cuiling Li,Jessica Gotay,Xin Wei Wang,Curtis C. Harris,Thomas Ried,Chu-Xia Deng +8 more
TL;DR: It is shown that mouse embryonic fibroblast cells carrying a targeted deletion of exon 11 of the Brca1 gene maintain an intact G1-S cell cycle checkpoint and proliferate poorly, however, a defective G2-M checkpoint in these cells is accompanied by extensive chromosomal abnormalities.
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Impaired DNA damage response, genome instability, and tumorigenesis in SIRT1 mutant mice.
Rui Hong Wang,Kundan Sengupta,Cuiling Li,Hyun-Seok Kim,Liu Cao,Cuiying Xiao,Sangsoo Kim,Xiaoling Xu,Yin Zheng,Beverly S. Chilton,Rong Jia,Zhi-Ming Zheng,Ettore Appella,Xin Wei Wang,Thomas Ried,Chu-Xia Deng +15 more
TL;DR: It is demonstrated that Sirt1(+/-) mice develop tumors in multiple tissues, whereas activation of SIRT1 by resveratrol treatment reduces tumorigenesis, and it is shown that many human cancers exhibit reduced levels ofSIRT1 compared to normal controls.