T
Thomas Santarius
Researcher at University of Cambridge
Publications - 128
Citations - 6185
Thomas Santarius is an academic researcher from University of Cambridge. The author has contributed to research in topics: Medicine & Meningioma. The author has an hindex of 31, co-authored 106 publications receiving 5010 citations. Previous affiliations of Thomas Santarius include Cambridge University Hospitals NHS Foundation Trust & Wellcome Trust Sanger Institute.
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Journal ArticleDOI
Identification of somatically acquired rearrangements in cancer using genome-wide massively parallel paired-end sequencing
Peter J. Campbell,Philip J. Stephens,Erin Pleasance,Sarah O’Meara,Heng Li,Thomas Santarius,Thomas Santarius,Lucy Stebbings,Catherine Leroy,Sarah Edkins,Claire Hardy,Jon W. Teague,Andrew Menzies,Ian Goodhead,Daniel J. Turner,C M Clee,Michael A. Quail,Antony V. Cox,Clive Gavin Brown,Richard Durbin,Matthew E. Hurles,Paul A.W. Edwards,Graham R. Bignell,Michael R. Stratton,P. Andrew Futreal +24 more
TL;DR: The results demonstrate the feasibility of systematic, genome-wide characterization of rearrangements in complex human cancer genomes, raising the prospect of a new harvest of genes associated with cancer using this strategy.
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A census of amplified and overexpressed human cancer genes
TL;DR: A weight-of-evidence based classification system for identifying individual genes in amplified regions that are selected for during tumour development was proposed in this article, where 77 genes for which there is good evidence of involvement in the development of human cancer were identified.
Journal ArticleDOI
Use of drains versus no drains after burr-hole evacuation of chronic subdural haematoma: a randomised controlled trial
Thomas Santarius,Peter J. Kirkpatrick,Dharmendra Ganesan,Hui Ling Chia,Ibrahim Jalloh,Peter Smielewski,Hugh K. Richards,Hani J. Marcus,Richard A Parker,Stephen J. Price,Ramez W. Kirollos,John D. Pickard,Peter J. Hutchinson +12 more
TL;DR: Use of a drain after burr-hole drainage of chronic subdural haematoma is safe and associated with reduced recurrence and mortality at 6 months.
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Mutation analysis of 24 known cancer genes in the NCI-60 cell line set.
Ogechi Ikediobi,Helen Davies,Graham R. Bignell,Sarah Edkins,Claire Stevens,Sarah O’Meara,Thomas Santarius,Tim Avis,Syd Barthorpe,Lisa Brackenbury,Gemma Buck,Adam Butler,Jody Clements,Jennifer Cole,Ed Dicks,Simon A. Forbes,Kristian Gray,Kelly Halliday,Rachel Harrison,Katy Hills,Jonathan Hinton,Christopher I. Hunter,Andy Jenkinson,David T. Jones,Vivienne Kosmidou,Richard Lugg,Andrew Menzies,Tatiana Mironenko,Adrian Parker,Janet Perry,Keiran Raine,David S. Richardson,Rebecca Shepherd,Alex Small,Raffaella Smith,Helen Solomon,Philip J. Stephens,Jon W. Teague,Calli Tofts,Jennifer Varian,Tony Webb,Sofie West,Sara Widaa,Andrew D. Yates,William C. Reinhold,John N. Weinstein,Michael R. Stratton,P. Andrew Futreal,Richard Wooster +48 more
TL;DR: Identification of those cancer genes mutated in the NCI-60, in combination with pharmacologic and molecular profiles of the cells, will allow for more informed interpretation of anticancer agent screening and will enhance the use of the NCi-60 cell lines for molecularly targeted screens.
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Chronic subdural haematoma: modern management and emerging therapies
TL;DR: An overview of the contemporary management of chronic subdural haematoma is provided and considerations regarding future approaches that could further optimize patient care and outcomes are presented.