T
Thomas Strub
Researcher at French Institute of Health and Medical Research
Publications - 25
Citations - 1340
Thomas Strub is an academic researcher from French Institute of Health and Medical Research. The author has contributed to research in topics: Microphthalmia-associated transcription factor & Melanoma. The author has an hindex of 10, co-authored 18 publications receiving 1061 citations. Previous affiliations of Thomas Strub include University of Strasbourg & Icahn School of Medicine at Mount Sinai.
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Journal ArticleDOI
A SUMOylation-defective MITF germline mutation predisposes to melanoma and renal carcinoma
Corine Bertolotto,Fabienne Lesueur,Sandy Giuliano,Thomas Strub,Mahaut de Lichy,Karine Bille,Philippe Dessen,Benoit d’Hayer,Hamida Mohamdi,Audrey Remenieras,Eve Maubec,Arnaud de la Fouchardière,Vincent Molinié,Pierre Vabres,Stéphane Dalle,N. Poulalhon,Tanguy Martin-Denavit,Luc Thomas,Pascale Andry-Benzaquen,Nicolas Dupin,F. Boitier,Annick Rossi,Jean-Luc Perrot,Bruno Labeille,Caroline Robert,Bernard Escudier,Olivier Caron,Laurence Brugières,Simon Saule,Betty Gardie,Sophie Gad,Stéphane Richard,Jérôme Couturier,Bin Tean Teh,Paola Ghiorzo,Lorenza Pastorino,Susana Puig,Celia Badenas,Håkan Olsson,Christian Ingvar,Etienne Rouleau,Rosette Lidereau,Philippe Bahadoran,Philippe Vielh,Eve Corda,Hélène Blanché,Diana Zelenika,Pilar Galan,François Aubin,Bertrand Bachollet,Celine Becuwe,Pascaline Berthet,Yves-Jean Bignon,Valérie Bonadona,Jean -Louis Bonafe,Marie -Noelle Bonnet-Dupeyron,Frédéric Cambazard,Jacqueline Chevrant-Breton,Isabelle Coupier,Sophie Dalac,Liliane Demange,Michel D'Incan,Catherine Dugast,Laurence Faivre,Lynda Vincent-Fetita,Marion Gauthier-Villars,Brigitte Gilbert,Florent Grange,Jean-Jacques Grob,Philippe Humbert,Nicolas Janin,Pascal Joly,Delphine Kerob,Christine Lasset,Dominique Leroux,Julien Levang,Jean -Marc Limacher,Cristina Bulai Livideanu,Michel Longy,Alain Lortholary,Dominique Stoppa-Lyonnet,Sandrine Mansard,Ludovic Mansuy,Karine Marrou,Christine Mateus,Christine Maugard,Nicolas Meyer,Catherine Noguès,Pierre Souteyrand,Laurence Venat-Bouvet,Hélène Zattara,Valérie Chaudru,Gilbert M. Lenoir,Mark Lathrop,Irwin Davidson,Marie-Françoise Avril,Florence Demenais,Robert Ballotti,Brigitte Bressac-de Paillerets +98 more
TL;DR: A germline missense substitution in MITF (Mi-E318K) is identified that occurred at a significantly higher frequency in genetically enriched patients affected with melanoma, RCC or both cancers, when compared with controls and provides insights into the link between SUMOylation, transcription and cancer.
Journal ArticleDOI
Essential role of microphthalmia transcription factor for DNA replication, mitosis and genomic stability in melanoma
Thomas Strub,Sandy Giuliano,Tao Ye,Caroline Bonet,Céline Keime,D Kobi,S Le Gras,Mireille Cormont,Robert Ballotti,Corine Bertolotto,Irwin Davidson +10 more
TL;DR: The identification of MITF-binding sites and gene-regulatory networks establish a framework for understanding oncogenic basic helix-loop-helix factors such as N-myc or TFE3 in other cancers.
Journal ArticleDOI
Histone Variant H2A.Z.2 Mediates Proliferation and Drug Sensitivity of Malignant Melanoma
Chiara Vardabasso,Alexandre Gaspar-Maia,Dan Hasson,Sebastian Pünzeler,David Valle-Garcia,Tobias Straub,Eva C. Keilhauer,Thomas Strub,Joanna Dong,Taniya Panda,Chi-Yeh Chung,Jonathan Yao,Rajendra Singh,Miguel F. Segura,Barbara Fontanals-Cirera,Amit Verma,Matthias Mann,Eva Hernando,Sandra B. Hake,Emily Bernstein +19 more
TL;DR: The integrated genomic analyses reveal that H2A.Z.2 is highly expressed in metastatic melanoma, correlates with decreased patient survival, and is required for cellular proliferation, and holds translational potential for novel therapeutic strategies.
Journal ArticleDOI
Transcription factor MITF and remodeller BRG1 define chromatin organisation at regulatory elements in melanoma cells
Patrick Laurette,Thomas Strub,Dana Koludrovic,Céline Keime,Stéphanie Le Gras,Hannah Seberg,Eric Van Otterloo,Hana Imrichova,Robert Siddaway,Stein Aerts,Robert A. Cornell,Gabrielle Mengus,Irwin Davidson +12 more
TL;DR: A comprehensive MITF interactome is defined identifying novel cofactors involved in transcription, DNA replication and repair, and chromatin organisation and it is shown that MITF interacts with a PBAF chromatin remodelling complex comprising BRG1 and CHD7.
Journal ArticleDOI
SIRT6 haploinsufficiency induces BRAF V600E melanoma cell resistance to MAPK inhibitors via IGF signalling
Thomas Strub,Flávia G. Ghiraldini,Saul Carcamo,Man Li,Aleksandra Wroblewska,Rajendra Singh,Matthew S. Goldberg,Dan Hasson,Zichen Wang,Stuart J. Gallagher,Peter Hersey,Avi Ma'ayan,Georgina V. Long,Richard A. Scolyer,Richard A. Scolyer,Brian D. Brown,Bin Zheng,Emily Bernstein +17 more
TL;DR: This study has not only identified an epigenetic mechanism of drug resistance, but also provides insights into a combinatorial therapy that may overcome resistance to standard-of-care therapy for BRAFV600-mutant melanoma patients.