T
Thomas Thomou
Researcher at Harvard University
Publications - 22
Citations - 3538
Thomas Thomou is an academic researcher from Harvard University. The author has contributed to research in topics: Adipose tissue & Adipogenesis. The author has an hindex of 19, co-authored 22 publications receiving 2934 citations. Previous affiliations of Thomas Thomou include Boston University & Mayo Clinic.
Papers
More filters
Journal ArticleDOI
Adipose-derived circulating miRNAs regulate gene expression in other tissues
Thomas Thomou,Marcelo A. Mori,Jonathan M. Dreyfuss,Jonathan M. Dreyfuss,Masahiro Konishi,Masaji Sakaguchi,Christian Wolfrum,Tata Nageswara Rao,Tata Nageswara Rao,Jonathon N. Winnay,Ruben Garcia-Martin,Steven K. Grinspoon,Phillip Gorden,C. Ronald Kahn +13 more
TL;DR: Transplantation of both white and brown adipose tissue—brown especially—into ADicerKO mice restores the level of numerous circulating miRNAs that are associated with an improvement in glucose tolerance and a reduction in hepatic Fgf21 mRNA and circulating FGF21.
Journal ArticleDOI
Mechanisms and Metabolic Implications of Regional Differences among Fat Depots
Tamara Tchkonia,Thomas Thomou,Yi Zhu,Iordanes Karagiannides,Charalabos Pothoulakis,Michael D. Jensen,James L. Kirkland +6 more
TL;DR: Fat distribution is closely linked to metabolic disease risk, and whether fat redistribution causes metabolic disease or whether it is a marker of underlying processes that are primarily responsible is an open question.
Journal ArticleDOI
Identification of depot-specific human fat cell progenitors through distinct expression profiles and developmental gene patterns.
Tamara Tchkonia,Marc E. Lenburg,Thomas Thomou,Nino Giorgadze,Garrett M. Frampton,Tamar Pirtskhalava,Andrew Cartwright,Mark Cartwright,John N. Flanagan,Iordanes Karagiannides,Norman P. Gerry,R. Armour Forse,Yourka D. Tchoukalova,Michael D. Jensen,Charalabos Pothoulakis,James L. Kirkland +15 more
TL;DR: It is found that genome-wide expression profiles of primary preadipocytes cultured in parallel from abdominal subcutaneous, mesenteric, and omental fat depots were distinct, consistent with differentFat depots being separate mini-organs.
Journal ArticleDOI
Role of MicroRNA Processing in Adipose Tissue in Stress Defense and Longevity
Marcelo A. Mori,Prashant Raghavan,Thomas Thomou,Thomas Thomou,Jeremie Boucher,Stacey Robida-Stubbs,Yazmín Macotela,Steven Russell,James L. Kirkland,T. Keith Blackwell,C. Ronald Kahn +10 more
TL;DR: It is shown that as mice age, there is downregulation of Dicer and miRNA processing in adipose tissue resulting in decreases of multiple miRNAs, which plays an important role in longevity and the ability of an organism to respond to environmental stress and age-related disease.
Journal ArticleDOI
Fat depot-specific characteristics are retained in strains derived from single human preadipocytes.
Tamara Tchkonia,Nino Giorgadze,Tamar Pirtskhalava,Thomas Thomou,Matthew DePonte,Ada Koo,R. Armour Forse,Dharmaraj Chinnappan,Carmen Martin-Ruiz,Thomas von Zglinicki,James L. Kirkland +10 more
TL;DR: Despite dividing 40 population doublings, hTERT strains derived from single preadipocytes retained fat depot–specific cell dynamic characteristics, consistent with heritable processes contributing to regional variation in fat tissue function.