T
Thomas V. Johnson
Researcher at Johns Hopkins University School of Medicine
Publications - 55
Citations - 2090
Thomas V. Johnson is an academic researcher from Johns Hopkins University School of Medicine. The author has contributed to research in topics: Transplantation & Intraocular pressure. The author has an hindex of 24, co-authored 42 publications receiving 1807 citations. Previous affiliations of Thomas V. Johnson include National Institutes of Health & University of Nebraska Medical Center.
Papers
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Journal ArticleDOI
Neuroprotective effects of intravitreal mesenchymal stem cell transplantation in experimental glaucoma.
Thomas V. Johnson,Natalie D. Bull,David Hunt,Nephtali Marina,Stanislav I. Tomarev,Keith R Martin +5 more
TL;DR: Local, but not systemic, transplantation of MSCs was neuroprotective in a rat glaucoma model to determine whether local or systemic bone marrow-derived mesenchymal stem cell (MSC) transplantation can confer neuroprotection in aRat model of laser-induced ocular hypertensive glau coma.
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Rodent models of glaucoma.
TL;DR: The numerous in vivo and in vitro rodent models of glaucoma are examined, the methods used to generate them are discussed, some of the major findings obtained in these models are summarized, and individual strengths and weaknesses for the various systems are identified.
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Development and characterization of an adult retinal explant organotypic tissue culture system as an in vitro intraocular stem cell transplantation model.
Thomas V. Johnson,Keith R Martin +1 more
TL;DR: Retinal explants prepared using the described techniques and cultured in B27/N2 medium are viable for at least 2 weeks and mimic in vivo glial reactivity to transplantation while allowing few grafted cells to integrate, and may be a useful in vitro model for investigating methods of enhancing retinal stem cell therapy.
Journal ArticleDOI
Identification of retinal ganglion cell neuroprotection conferred by platelet-derived growth factor through analysis of the mesenchymal stem cell secretome.
Thomas V. Johnson,Nicholas W. DeKorver,Victoria A. Levasseur,Andrew Osborne,Alessia Tassoni,Barbara Lorber,Janosch P. Heller,Rafael Villasmil,Natalie D. Bull,Keith R Martin,Stanislav I. Tomarev +10 more
TL;DR: This paper showed that mesenchymal stem cells secrete a number of neuroprotective proteins and suggest that platelet-derived growth factor secretion in particular may play an important role.
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Identification of Barriers to Retinal Engraftment of Transplanted Stem Cells
TL;DR: It is demonstrated that the ECM of the inner basal lamina is neither necessary nor sufficient to prevent migration of transplanted cells into the neural retina, and targeted disruption of glial reactivity dramatically improved the structural integration of intravitreally transplants cells.