Thomas W. Stephens

TL;DR: Serum leptin concentrations are correlated with the percentage of body fat, suggesting that most obese persons are insensitive to endogenous leptin production.

TL;DR: In this paper, a truncated inactive protein was found to suppress food intake and decrease body weight in normal and ob/ob mice but not db/db (diabetic) mice, which are thought to lack the appropriate receptor.

TL;DR: The nocturnal rise in leptin observed in the present study resembles those reported for prolactin, thyroid-stimulating hormone, and free fatty acids and is speculated to have an effect in suppressing appetite during the night while sleeping.

TL;DR: In lean subjects with relatively low adipose tissue, the majority of circulating leptin is in the bound form and thus may not be available to brain receptors for its inhibitory effects on food intake both under normal and food deprivation states.

TL;DR: It is shown that leptin treatment down-regulates endogenous adipose ob mRNA, however, treatment of isolated rat adipocytes with 100 ng/ml human or murine leptin had no direct effect on expression of endogenous ob RNA, suggesting that leptin may be able to down- Regulate its own expression by an indirect, non-autocrine mechanism.