T
Thorsten Heinekamp
Researcher at Leibniz Association
Publications - 83
Citations - 4591
Thorsten Heinekamp is an academic researcher from Leibniz Association. The author has contributed to research in topics: Aspergillus fumigatus & Gliotoxin. The author has an hindex of 33, co-authored 75 publications receiving 3956 citations. Previous affiliations of Thorsten Heinekamp include Schiller International University & University of Maryland, Baltimore.
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The akuB(KU80) mutant deficient for nonhomologous end joining is a powerful tool for analyzing pathogenicity in Aspergillus fumigatus.
Márcia Eliana da Silva Ferreira,Marcia Regina von Zeska Kress,Marcela Savoldi,Maria Helena S. Goldman,Albert Härtl,Thorsten Heinekamp,Axel A. Brakhage,Gustavo H. Goldman +7 more
TL;DR: To increase the frequency of homologous recombination, the KU80 homologue in Aspergillus fumigatus was inactivated and deletion had no influence on pathogenicity in a low-dose murine infection model.
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HapX-mediated adaption to iron starvation is crucial for virulence of Aspergillus fumigatus.
Markus Schrettl,Nicola Beckmann,John J. Varga,Thorsten Heinekamp,Ilse D. Jacobsen,Christoph Jöchl,Tarek A. A. Moussa,Shaohua Wang,Fabio Gsaller,Michael Blatzer,Ernst R. Werner,William C. Niermann,Axel A. Brakhage,Hubertus Haas +13 more
TL;DR: In this paper, the bZIP-type regulator HapX is indispensable for the transcriptional remodeling required for adaption to iron starvation in the opportunistic fungal pathogen Aspergillus fumigatus.
Journal Article
HapX-Mediated Adaption to Iron Starvation Is Crucial for Virulence of Aspergillus fumigatus RID F-4349-2010
TL;DR: It is demonstrated that HapX-dependent adaption to conditions of iron starvation is crucial for virulence of A. fumigatus, a opportunistic fungal pathogen facing iron starvation in the host.
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SreA‐mediated iron regulation in Aspergillus fumigatus
Markus Schrettl,H. Stanley Kim,Martin Eisendle,Claudia Kragl,William C. Nierman,William C. Nierman,Thorsten Heinekamp,Ernst R. Werner,Ilse D. Jacobsen,Paul Illmer,Hyojeong Yi,Axel A. Brakhage,Hubertus Haas +12 more
TL;DR: During iron‐replete conditions, SreA deficiency partially derepressed synthesis of triacetylfusarinine C and uptake of iron resulting in increased cellular accumulation of both iron and ferricrocin, underscoring that A.’fumigatus faces iron‐depleted conditions during infection.
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Production of Pyomelanin, a Second Type of Melanin, via the Tyrosine Degradation Pathway in Aspergillus fumigatus
Jeannette Schmaler-Ripcke,Venelina Sugareva,Peter Gebhardt,Robert Winkler,Olaf Kniemeyer,Thorsten Heinekamp,Axel A. Brakhage +6 more
TL;DR: It is shown that Aspergillus fumigatus is able to produce an alternative melanin, i.e., pyomelanin, by a different pathway, starting from l-tyrosine, similar to that in humans leading to alkaptomelAnin.