T
Thorsten R. Mempel
Researcher at Harvard University
Publications - 92
Citations - 14500
Thorsten R. Mempel is an academic researcher from Harvard University. The author has contributed to research in topics: T cell & Cytotoxic T cell. The author has an hindex of 43, co-authored 86 publications receiving 12532 citations. Previous affiliations of Thorsten R. Mempel include Max Planck Society & Ludwig Maximilian University of Munich.
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Journal ArticleDOI
Identification of splenic reservoir monocytes and their deployment to inflammatory sites
Filip K. Swirski,Matthias Nahrendorf,Martin Etzrodt,Martin Etzrodt,Moritz Wildgruber,Virna Cortez-Retamozo,Peter Panizzi,Jose-Luiz Figueiredo,Rainer H. Kohler,Aleksey Chudnovskiy,Peter Waterman,Elena Aikawa,Thorsten R. Mempel,Peter Libby,Ralph Weissleder,Mikael J. Pittet +15 more
TL;DR: It is shown that bona fide undifferentiated monocytes reside in the spleen and outnumber their equivalents in circulation and identifies splenic monocytes as a resource that the body exploits to regulate inflammation.
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T-cell priming by dendritic cells in lymph nodes occurs in three distinct phases
TL;DR: T-cell priming by DCs occurs in three successive stages: transient serial encounters during the first activation phase are followed by a second phase of stable contacts culminating in cytokine production, which makes a transition into a third phase of high motility and rapid proliferation.
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Homing and cellular traffic in lymph nodes
TL;DR: New insights are covered into the organization and microvascular specialization of LNs, the guidance mechanisms that allow lymphocytes and antigen-presenting cells to find their correct place in the nodal parenchyma; and the role of afferent lymph flow in LN function.
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Subcapsular sinus macrophages in lymph nodes clear lymph-borne viruses and present them to antiviral B cells
Tobias Junt,E. Ashley Moseman,Matteo Iannacone,Steffen Massberg,Philipp A. Lang,Marianne Boes,Katja Fink,Sarah E. Henrickson,Dmitry M. Shayakhmetov,Nelson C. Di Paolo,Nico van Rooijen,Thorsten R. Mempel,Sean P. J. Whelan,Ulrich H. von Andrian +13 more
TL;DR: Findings indicate that CD169+ macrophages have a dual physiological function that acts as innate ‘flypaper’ by preventing the systemic spread of lymph-borne pathogens and as critical gatekeepers at the lymph–tissue interface that facilitate the recognition of particulate antigens by B cells and initiate humoral immune responses.
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Orchestrating the orchestrators: chemokines in control of T cell traffic
TL;DR: Advances in understanding of how chemokines orchestrate the trafficking and activity of immune cells has increased considerably are reviewed with particular emphasis on control of the migration of T cell subsets in lymph nodes and in peripheral tissues in homeostasis and inflammation.