Tianlu Chen

TL;DR: In this article, the authors performed a serum metabolic analysis to test the hypothesis that the distinct metabolite profiles of malignant tumors are reflected in biofluids, and identified 33 metabolites from 64 colorectal cancer (CRC) patients and 65 healthy controls using gas chromatography time-of-flight mass spectrometry (GC−TOFMS) and Acquity ultraperformance liquid chromatography quadrupole time of flight mass analyzer (Acquity UPLC−QTOFMs).

TL;DR: Theabrownin alters the gut microbiota in mice and humans, predominantly suppressing microbes associated with bile-salt hydrolase (BSH) activity, and it is suggested that decreased intestinal BSH microbes and/or decreased FXR-FGF15 signaling may be potential anti- hypercholesterolemia and anti-hyperlipidemia therapies.

TL;DR: This study comprehensively compared eight imputation methods for missing value imputation for different types of missing values using four metabolomics datasets and demonstrated that RF performed the best for MCAR/MAR and QRILC was the favored one for left-censored MNAR.

TL;DR: This work shows that metabolomic profiling approach is a promising screening tool for the diagnosis and stratification of HCC patients with alpha fetoprotein values lower than 20 ng/ml with an accuracy of 100% using a panel of metabolite markers.

TL;DR: A global metabolic profiling study involving 112 schizophrenic patients and 110 healthy subjects, who were divided into a training set and a test set, designed to identify metabolite markers found multiple fatty acids and ketone bodies elevated, suggesting an upregulated fatty acid catabolism in the brains of schizophrenia patients.